The evolution of recombination and genomic structures : a modelling approach
type: Dataset
description: Meiotic recombination plays several critical roles in molecular evolution. First, recombination represents a key step in the production and transmission of gametes during meiosis. Second, recombination facilitates the impact of natural selection by shuffling genomic sequences. Furthermore, the action of certain repair mechanisms during recombination affects the frequencies of alleles in populations via biased gene conversion. Lately, the numerous advancements in the study of recombination have unraveled the complexity of this process regarding both its mechanisms and evolution. The main aim of this thesis is to analyze the relationships between the different causes, characteristics, and effects of recombination from an evolutionary perspective. First, we developed a model based on the control mechanisms of meiosis and inter-crossover interference. We further used this model to compare the recombination strategies in multiple vertebrates and invertebrates, as well as between sexes. Second, we studied the impact of the sex-specific localization of recombination hotspots on the evolution of the GC content for several vertebrates. Last, we built a population genetics model to analyze the impact of recombination on the frequency of deleterious mutation in the human population.
landing page: https://theses.hal.science/tel-00840809
identifier: NNT: 2011LYO10087
keyword: biased-gene-conversion
keyword: conversion-genique-biaisee
keyword: equilibre-du-contenu-en-gc
keyword: equilibrium-gc-content
keyword: evolution
keyword: heterochiasme
keyword: heterochiasmy
keyword: infoeu-reposemanticsdoctoralthesis
keyword: interference
keyword: recombinaison
keyword: recombination
keyword: sdvsalife-sciences-q-bioagricultural-sciences
keyword: theses
issued: 2026-05-10T11:54:31.491725
modified: 2026-05-10T11:54:31.491729
language: en
contact point: Organization
  fn: CCSD

test_moissonnage_selune
type: Agent

The evolution of recombination and genomic structures : a modelling approach
type: Distribution
format: HTML
access URL: https://theses.hal.science/tel-00840809
issued: 2026-05-10T11:54:31.509583
modified: 2026-05-10T11:54:31.474124