@prefix dcat: . @prefix dct: . @prefix foaf: . @prefix vcard: . @prefix xsd: . a dcat:Dataset ; dct:description """ The hijacking of cellular machinery by pathogens, is essential to spread through the body of the host. Perturbation of signaling pathways that control cell homeostasis is a strategy developed by many other viruses upon infection. One originality of rabies virus is that it induces survival of infected neurons to ensure its propagation. The PDZ binding site (PDZ-BS) of the glycoprotein of rabies virus was identified as a key element to control survival and apoptosis pathways. The PDZ-BS of the glycoprotein from the virulent strain recognizes only two isoforms of the Microtubule Associated Serine/Threonine kinase family (MAST1 and MAST2). MAST2 acts as a survival inhibitor that stimulates neurite retraction and inhibits their elongation. In addition MAST2 interacts with the PDZ-BS of the phosphatase PTEN that is another inhibitor of neuronal survival. We propose that the glycoprotein disrupts the PTEN/MAST2 complex by competition with the PDZ-BS of PTEN and disturbs cellular homeostasis. The structure of the PDZ domain of MAST2 complexed with its endogenous ligand (PTEN13-Cter) reveals an original interaction with a large surface of interaction. This interaction network is preserved in MAST2 PDZ domain complexed with the viral ligand (Cyto13-vir). We demonstrated that the PDZ-BS of the glycoprotein is essential to trigger neuronal survival and that it induces a partial exclusion of PTEN from the nucleus. It is well established that the phosphorylation of PTEN is controlled by its phosphorylation state """ ; dct:identifier "NNT: 2012PAO66292" ; dct:issued "2026-05-10T13:00:06.855808"^^xsd:dateTime ; dct:language "fr" ; dct:modified "2026-05-10T13:00:06.855814"^^xsd:dateTime ; dct:publisher ; dct:title "MAST 2 involvement in the mechanism of neuronal survival pathways induced by the rabies glycoprotein" ; dcat:contactPoint [ a vcard:Organization ; vcard:fn "CCSD" ] ; dcat:distribution ; dcat:keyword "domaine-pdz", "infoeu-reposemanticsdoctoralthesis", "kinase", "mast2", "pten", "sdvbbmbplife-sciences-q-biobiochemistry-molecular-biologybiophysics", "survie-neuronale", "theses", "virus-de-la-rage" ; dcat:landingPage . a dcat:Distribution ; dct:format "HTML" ; dct:issued "2026-05-10T13:00:06.858405"^^xsd:dateTime ; dct:modified "2026-05-10T13:00:06.838902"^^xsd:dateTime ; dct:title "MAST 2 involvement in the mechanism of neuronal survival pathways induced by the rabies glycoprotein" ; dcat:accessURL . a foaf:Agent ; foaf:name "test_moissonnage_selune" . a foaf:Document .