@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00839459v1> a dcat:Dataset ;
    dct:description """
              We have studied, in the lung adenocarcinomas bearing EGFR or KRAS mutations, TP53/p14arf status, and in the non-small cell lung cancer the contribution of Neurotensin system (NTS/NTSR1) on the tumoral progression and survival. In a series of 96 patients, TP53, KRAS and EGFR mutations were detected in 45.2 %, 15.8 % and 34.4 % of the cases, respectively. The p14arf decrease expression was observed in 57.1 % of the cases. The p53/p14arf deficit was observed in 83.3 % and 76.9% of EGFR and KRAS mutated tumors, respectively. Our results showed that the inactivation of the p53/p14arf pathway is common but not systematic in EGFR or KRAS mutated lung adenocarcinomas. Labeling of NTS and NTSR1 was found in 60.4 % of stage I (n = 139), 47% of stage II (n = 74), and 50% of stage III (n = 133) adenocarcinomas. In univariate and multivariate analysis, NTSR1 expression were significantly associated with a poor prognosis in terms of overall survival (p = 0.0081 for stage I, p = 0.0087 for stage II-III). In vivo and in vitro studies have shown that the complex NTS/NTSR1 promotes tumor progression by increasing HER2 and HER3 expression and EGFR, HER3 and HER2 activation. This latter was mediated by MMP1 activation and HB-EGF and NRG1 released. This work supports the hypothesis that complex NTS/NTSR1 actively contributes to the aggressiveness and bronchial tumor progression
            """ ;
    dct:identifier "NNT: 2012PAO66552" ;
    dct:issued "2026-05-10T13:03:27.906859"^^xsd:dateTime ;
    dct:language "fr" ;
    dct:modified "2026-05-10T13:03:27.906863"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Study of the relationship between EGFR/KRAS mutations and p53/p14arf alterations and characterization of novel therapeutic target, the neurotensin and its receptor1 complex, in non-small cell lung cancer" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00839459v1/resource/e43d8b38-4e28-4446-8f47-a2dfbd87e9bf> ;
    dcat:keyword "cancer-bronchique-non-a-petites-cellules",
        "egfr",
        "infoeu-reposemanticsdoctoralthesis",
        "neurotensine",
        "p53",
        "progression-tumorale",
        "recepteur-de-la-neurotensine",
        "sdvcanlife-sciences-q-biocancer",
        "theses" ;
    dcat:landingPage <https://theses.hal.science/tel-00839459> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00839459v1/resource/e43d8b38-4e28-4446-8f47-a2dfbd87e9bf> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-10T13:03:27.910195"^^xsd:dateTime ;
    dct:modified "2026-05-10T13:03:27.897053"^^xsd:dateTime ;
    dct:title "Study of the relationship between EGFR/KRAS mutations and p53/p14arf alterations and characterization of novel therapeutic target, the neurotensin and its receptor1 complex, in non-small cell lung cancer" ;
    dcat:accessURL <https://theses.hal.science/tel-00839459> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .

<https://theses.hal.science/tel-00839459> a foaf:Document .