Elaboration of multifunctional silica-based hybrid nanoparticles by reverse microemulsion : application to the design of an antibacterial agent
type: Dataset
description: This thesis aims at developing hybrid nanoparticles based on silica by reverse microemulsion. The silica nanoparticles are the basic matrix containing and protecting organic molecules and/or metallic nanoparticles. The combined incorporation of different entities within the silica opens wide prospects for the introduction of new properties related to the hybrid structure. To develop such objects, we used reverse micelles based on water, Triton X-100, hexanol and cyclohexan as reaction medium. The influence of operating conditions on the control of the size of reverse micelles was first studied. These micelles were then set to be used as nanoreactors for the synthesis of silica nanoparticles by sol-gel using suitable alkoxysilanes precursors. We monitored how it was possible to control the size of silica nanoparticles based on the water to surfactant ratio. It was thus possible to prepare in a reproducible way nanoparticles with sizes varying from 30 nm to 200 nm. We then investigated the possibility to encapsulate, in this nanoscaled matrix, fluorophores and nanoparticles of gold and silver in a controlled manner. To ensure a good colloidal stability in solution, these hybrid nanoparticles were, on the one hand, modified by adding a functional silane and, on the other hand, by click chemistry. We have thus shown that it is possible to perform, in a same micellar media, all of manufacturing process of the hybrid nanoparticle, from the silica matrix to its functionalization passing by the incorporation of functional entities. This method of sequential synthesis allowed us to bypass the purification and redispersion steps that can be problematic in the conventional methods. All this work has been extended to the design of an antibacterial agent based of silver/silica nanoparticles, capable of preventing bacterial growth through the gradual release of silver ions. Tests conducted in solution on the impregnated cotton and polyethylene terephtalate indeed show an interest…
identifier: NNT: 2010LYO10281
issued: 2026-05-10T13:35:39.730618
language: fr
modified: 2026-05-10T13:35:39.730623
contact point: Organization
  fn: CCSD
keyword: antibacterial
keyword: antibacterien
keyword: argent
keyword: chimothechemical-sciencesother
keyword: click-chemistry
keyword: coreshell
keyword: coton
keyword: cotton
keyword: curcoquille
keyword: encapsulation
keyword: fluorescent
keyword: gold
keyword: infoeu-reposemanticsdoctoralthesis
keyword: micelle-inverse
keyword: multifonctionnel
keyword: multifunctional
keyword: nanoparticles
keyword: nanoparticules
keyword: one-pot
keyword: or
keyword: pet
keyword: reverse-micelle
keyword: silica
keyword: silice
keyword: silver
keyword: theses
landing page: https://theses.hal.science/tel-00838729

Elaboration of multifunctional silica-based hybrid nanoparticles by reverse microemulsion : application to the design of an antibacterial agent
type: Distribution
format: HTML
issued: 2026-05-10T13:35:39.763963
modified: 2026-05-10T13:35:39.707674
access URL: https://theses.hal.science/tel-00838729

test_moissonnage_selune
type: Agent