@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

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              Our team has recently built a polyvalent method that gives complex functionalized C60 hexa-adducts. This methodology permits to obtain products with original features. C60 acts as an inert scaffold, around which functionnalities are distributed in a well-defined octahedral space. The first part of this thesis describes exploitation of this methodology to create polycationics C60 hexa-adducts, which have shown remarkable gene delivery capabilities. Next, the synthetized polyamine dendrons were used to build supramolecular structure of C60 hexa-adducts, as micellar forms. The study of these self-assembled structures has guided us to design micelles of mannosylated C60 hexa-adducts, which biological applications are under investigation. In parallel a covalent synthesis has furnished a dendrimers-like multimannosylated C60 hexa-adduct. Based on the observation that our methodology to create C60 hexa-adduct is efficient only for a specific regio-selectivity, the last part of this thesis was devoted to the development of new synthetic routes to obtain C60 derivates with an original regio-selective control.
            """ ;
    dct:identifier "NNT: 2013STRAF010" ;
    dct:issued "2026-05-10T16:54:04.981354"^^xsd:dateTime ;
    dct:language "fr" ;
    dct:modified "2026-05-10T16:54:04.981359"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Design, synthesis and study of functionalized C60 : biological applications and methodological development" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
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    dcat:keyword "amphiphile",
        "amphiphiles",
        "auto-assemblages",
        "c60",
        "chimothechemical-sciencesother",
        "dendrimer",
        "dendrimers",
        "infoeu-reposemanticsdoctoralthesis",
        "micelles",
        "polydiacetylenes",
        "self-assembling",
        "theses",
        "transfection" ;
    dcat:landingPage <https://theses.hal.science/tel-00834861> .

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    dct:issued "2026-05-10T16:54:04.997903"^^xsd:dateTime ;
    dct:modified "2026-05-10T16:54:04.967389"^^xsd:dateTime ;
    dct:title "Design, synthesis and study of functionalized C60 : biological applications and methodological development" ;
    dcat:accessURL <https://theses.hal.science/tel-00834861> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .

<https://theses.hal.science/tel-00834861> a foaf:Document .