test_moissonnage_selune
type: Agent

Design, synthesis and study of functionalized C60 : biological applications and methodological development
type: Dataset
contact point: Organization
  fn: CCSD
keyword: chimothechemical-sciencesother
keyword: infoeu-reposemanticsdoctoralthesis
keyword: micelles
keyword: amphiphile
keyword: polydiacetylenes
keyword: c60
keyword: auto-assemblages
keyword: dendrimer
keyword: dendrimers
keyword: amphiphiles
keyword: theses
keyword: self-assembling
keyword: transfection
landing page: https://theses.hal.science/tel-00834861
description: Our team has recently built a polyvalent method that gives complex functionalized C60 hexa-adducts. This methodology permits to obtain products with original features. C60 acts as an inert scaffold, around which functionnalities are distributed in a well-defined octahedral space. The first part of this thesis describes exploitation of this methodology to create polycationics C60 hexa-adducts, which have shown remarkable gene delivery capabilities. Next, the synthetized polyamine dendrons were used to build supramolecular structure of C60 hexa-adducts, as micellar forms. The study of these self-assembled structures has guided us to design micelles of mannosylated C60 hexa-adducts, which biological applications are under investigation. In parallel a covalent synthesis has furnished a dendrimers-like multimannosylated C60 hexa-adduct. Based on the observation that our methodology to create C60 hexa-adduct is efficient only for a specific regio-selectivity, the last part of this thesis was devoted to the development of new synthetic routes to obtain C60 derivates with an original regio-selective control.
identifier: NNT: 2013STRAF010
issued: 2026-05-10T16:54:04.981354
language: fr
modified: 2026-05-10T16:54:04.981359

Design, synthesis and study of functionalized C60 : biological applications and methodological development
type: Distribution
access URL: https://theses.hal.science/tel-00834861
format: HTML
issued: 2026-05-10T16:54:04.997903
modified: 2026-05-10T16:54:04.967389