Chemical modifications of polysaccharides and their hydrogels by “click chemistry”
type: Dataset
description: This work is part of a current field that has grown steadily in recent years and aims to obtain and characterize amphiphilic polymers and hydrogels with controlled hydrophilicity, derived from natural polymers, with potential use as controlled drug delivery systems. Acting in contact with the body or inside it, it is necessary that the polymers used to obtain these architectures meet a number of constraints to be non-toxic, biocompatible and biodegradable. For these reasons, most of the time natural polymers are chosen, especially those from the class of polysaccharides, but there are also synthetic polymers that meet these requirements. Thus, the materials considered were: starch, poly (ε-caprolactone), palmitoyl chloride, citric acid, their by-products of degradation being non toxic. The thesis is divided into two parts, one theoretical and one experimental, and structured into five chapters, wherein: the first chapter is the theoretical and the others, the original, experimental part. In a first time, starch was hydrophobized by grafting poly-caprolactone using "click chemistry" (CuAAC) (using the traditional way and the one using the microwaves) between starch chains bearing alkyne side functions and polycaprolactone chains with azide chain end function, these latter being synthesized by ROP of caprolactone. Another way consists in the esterification with long fatty acid chains. Physico-chemical analysis, morphological and the behavior in different solutions have been made to obtain information about both the structure and the characteristics of the products. in a second part, hydrogels based on starch and modified starch with fatty acid chains or PCL and crosslinked with citric acid have been obtained. To achieve the objectives, a strategy with two experimental independent variables was used, the mathematical modeling of experimental data giving information on the existing phenomena, and showing the synergistic effects and at the same time establishing the cond…
identifier: NNT: 2011LYO10220
issued: 2026-05-10T17:06:01.648669
language: ro
modified: 2026-05-10T17:06:01.648673
contact point: Organization
  fn: CCSD
keyword: amidon
keyword: amphiphilic-polymers
keyword: chimothechemical-sciencesother
keyword: click-chemistry
keyword: copolymeres-amphiphiles
keyword: hydrogels
keyword: infoeu-reposemanticsdoctoralthesis
keyword: polycaprolactone
keyword: starch
keyword: theses
keyword: vectorisation
keyword: vectorization
landing page: https://theses.hal.science/tel-00834679

Chemical modifications of polysaccharides and their hydrogels by “click chemistry”
type: Distribution
format: HTML
issued: 2026-05-10T17:06:01.671113
modified: 2026-05-10T17:06:01.632601
access URL: https://theses.hal.science/tel-00834679

test_moissonnage_selune
type: Agent