@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00834352v1> a dcat:Dataset ;
    dct:description """
              Dysregulated activation of T cells leads to pathogenic immune response to self-antigens. Despite an increasing use of high dose therapy of intravenous gammaglobulin (IVIg) in the treatment of T-cell and autoantibody-mediated inflammatory and autoimmune diseases, comprehension of the mechanisms underlying its therapeutic benefit has remained a major challenge. Particularly, the effect of IVIg in T cell mediated autoimmune conditions remains unexplored. I have investigated the effect of high dose IVIg on T cell polarization using actively induced experimental autoimmune encephalomyelitis (EAE), a T cell-mediated autoimmune condition. IVIg inhibits the differentiation of naïve CD4 T cells into effector subsets (Th1 and Th17 cells) and concomitantly induces an expansion of Foxp3+ regulatory cells. IVIg decreases the tissue damaging potential of pathogenic T cells by down regulating GM-CSF and podoplanin. Additionally, IVIg circumvents the neuronal damage by inhibiting the infiltration of CD4 T lymphocytes to the central nervous system by restraining their egress from the DLN through S1P-S1P1-mTOR pathway. Intriguingly and contrary to the current arguments, the inhibitory FcγRIIB and sialylation of IgG are dispensable for IVIg-mediated reciprocal modulation of effector and regulatory CD4 subsets. Altogether, therapeutic benefit of IVIg in EAE involves shifting the balance from Th17/Th1 towards Treg, down-regulating encephalitogenic mediators and inhibition of T cell trafficking to the target organ.
            """ ;
    dct:identifier "NNT: 2012PA066113" ;
    dct:issued "2026-05-10T17:12:33.983800"^^xsd:dateTime ;
    dct:language "en" ;
    dct:modified "2026-05-10T17:12:33.983804"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Intervenous immunoglobulins as modulators of immune response : effect on T cell polarisation, pathogenicity and trafficking" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00834352v1/resource/7cda33d8-9590-403d-9126-7905083085dd> ;
    dcat:keyword "auto-immunite",
        "cible-de-la-rapamycine-chez-les-mammiferes-mtor",
        "encephalomyelite-auto-immune-experimentale-eae",
        "immunoglobulines-naturelles",
        "infoeu-reposemanticsdoctoralthesis",
        "lymphocytes-t",
        "sdvimmlife-sciences-q-bioimmunology",
        "sphingosine-1-phosphate-s1p1",
        "theses" ;
    dcat:landingPage <https://theses.hal.science/tel-00834352> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00834352v1/resource/7cda33d8-9590-403d-9126-7905083085dd> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-10T17:12:33.997153"^^xsd:dateTime ;
    dct:modified "2026-05-10T17:12:33.973806"^^xsd:dateTime ;
    dct:title "Intervenous immunoglobulins as modulators of immune response : effect on T cell polarisation, pathogenicity and trafficking" ;
    dcat:accessURL <https://theses.hal.science/tel-00834352> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .

<https://theses.hal.science/tel-00834352> a foaf:Document .