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@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

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    dct:description """
              G-quadruplexes are topologically diverse four-stranded structures formed by certain G-rich nucleic acids in physiological conditions in vitro. During my thesis, I studied their in vivo formation, and the pathological consequences of their persistency. The experimental system used during my thesis rely on the measurement of the stability of human tandemly-repeated sequences called "minisatellite" in mitotically growing S. cerevisiae. The unitary motif of CEB1 form a G-quadruplex in vitro, efficiently unwound by the purified Pif1 helicase. In a Pif1-deficient strain, CEB1 is frequently rearranged (expansion and contraction). At first, we showed that this CEB1 instability was dependent on its G-quadruplex-forming motifs, by directed mutagenesis. I confirmed this result by treating cells with a specific G-quadruplex ligand: it specifically induces the instability of CEB1, but not its G-mutated counterpart. In collaboration with J. Lopes, I showed that the CEB1 instability occurred during replication, upon formation of G-quadruplexes in the leading strand template. The ability to form G-quadruplexes, among other GC-rich minisatellite features, induces gross chromosomal rearrangements. The last aspect of my thesis consisted in the study of the structure-function relationship of G-quadruplexes and genomic instability
            """ ;
    dct:identifier "NNT: 2012PAO66445" ;
    dct:issued "2026-05-10T18:06:24.760699"^^xsd:dateTime ;
    dct:language "fr" ;
    dct:modified "2026-05-10T18:06:24.760704"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Role of G-quadruplexes in the induction of genomic instability in S. cerevisiae" ;
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    dcat:keyword "g-quadruplexe",
        "infoeu-reposemanticsdoctoralthesis",
        "instabilite-genomique",
        "levure",
        "minisatellite",
        "pif1",
        "replication",
        "sdvbbmlife-sciences-q-biobiochemistry-molecular-biology",
        "theses" ;
    dcat:landingPage <https://theses.hal.science/tel-00833453> .

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    dct:issued "2026-05-10T18:06:24.782226"^^xsd:dateTime ;
    dct:modified "2026-05-10T18:06:24.744622"^^xsd:dateTime ;
    dct:title "Role of G-quadruplexes in the induction of genomic instability in S. cerevisiae" ;
    dcat:accessURL <https://theses.hal.science/tel-00833453> .

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