@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00832985v1> a dcat:Dataset ;
    dct:description """
              During development, the posterior brain undergoes a transient segmentation process along the anteroposterior axis leading to its subdivision into 7 transversal units called rhombomeres (r) that form developmental and genetic expression units. The zinc finger factor plays a key role in this process by coupling the formation and the specification of the rhombomeres 3 and 5. Three regulatory elements controlling Krox20 expression have been characterized previously. Elements B and C are active in r5 and in r3-r5, respectively, and are involved in the onset of Krox20 expression whose amplification and upkeep are carried out by the autoregulatory element A. Thus, element C is a key tool to investigate the mechanisms responsible for the regionalized expression of Krox20 in r3. In order to deepen the characterization of Krox20 transcriptional control in r3, I undertook a functional analysis of the sequences of element C by mutagenesis and identified several conserved blocks required for its activity in r3. Furthermore, I established the complete quantitative and differential transcriptomic map of the mouse early hindbrain by RNA-Seq and I characterized several regulators of element C activity. Finally, I analyzed the mouse mutant where element C is deleted and I revealed new properties of Krox20 transcriptional control, notably a cis-cooperation between elements A and C. As a conclusion, this work shows how the combination of different approaches allows the elucidation of a complex transcriptional regulation mechanism that plays an essential role in cell specification
            """ ;
    dct:identifier "NNT: 2012PAO66518" ;
    dct:issued "2026-05-10T18:30:14.582018"^^xsd:dateTime ;
    dct:language "fr" ;
    dct:modified "2026-05-10T18:30:14.582022"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Cis-regulatory element and trans factors controlling Krox20 expression during hindbrain segmentation" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00832985v1/resource/c5f0616d-4052-4694-9c28-d0aac72414d1> ;
    dcat:keyword "element-regulateur",
        "facteurs-de-transcription",
        "infoeu-reposemanticsdoctoralthesis",
        "regulation-transcriptionnelle",
        "rhombencephale",
        "rna-seq",
        "sdvbddlife-sciences-q-biodevelopment-biology",
        "segmentation",
        "theses" ;
    dcat:landingPage <https://theses.hal.science/tel-00832985> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00832985v1/resource/c5f0616d-4052-4694-9c28-d0aac72414d1> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-10T18:30:14.592431"^^xsd:dateTime ;
    dct:modified "2026-05-10T18:30:14.571035"^^xsd:dateTime ;
    dct:title "Cis-regulatory element and trans factors controlling Krox20 expression during hindbrain segmentation" ;
    dcat:accessURL <https://theses.hal.science/tel-00832985> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .

<https://theses.hal.science/tel-00832985> a foaf:Document .