@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

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    dct:description """
              The aim of this thesis was the development of different supramolecular approaches, like MS and IM-MS, to characterize precisely protein/ligand interaction and to analyze complex mixtures of proteins. Understanding of supramolecular MS instruments and instrumental and methodological optimizations were allowed the development of MS and IM-MS to characterize very high mass supramolecular assembly. Thus, we were able to follow by kinetic the formation of protein/ligand interaction as well as associated conformational modifications, showing the interest of IM-MS coupling in pharmaceutical research. Furthermore, this work deals with the study of high mass complexes and assessment of IM-MS to obtain structural information on these complexes. As a consequence, we have pushed away some limits of MS allowing the use of this technique in structural biology.
            """ ;
    dct:identifier "NNT: 2012STRAF036" ;
    dct:issued "2026-05-10T18:59:43.365345"^^xsd:dateTime ;
    dct:language "fr" ;
    dct:modified "2026-05-10T18:59:43.365351"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Mass spectrometry and ion mobility developments to the study of supramolecular biological complexes" ;
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    dcat:keyword "infoeu-reposemanticsdoctoralthesis",
        "interaction-proteine-ligand",
        "ion-mobility-im-ms",
        "mobilite-ionique",
        "non-covalent",
        "physcondcm-genphysics-physicscondensed-matter-cond-matother-cond-matother",
        "proteinligand",
        "ribosome",
        "spectrometrie-de-masse",
        "structural-biology",
        "supramoleculaire",
        "supramolecular-mass-spectrometry-ms",
        "theses" ;
    dcat:landingPage <https://theses.hal.science/tel-00832488> .

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    dct:issued "2026-05-10T18:59:43.383059"^^xsd:dateTime ;
    dct:modified "2026-05-10T18:59:43.350421"^^xsd:dateTime ;
    dct:title "Mass spectrometry and ion mobility developments to the study of supramolecular biological complexes" ;
    dcat:accessURL <https://theses.hal.science/tel-00832488> .

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