ONCOLOGY NANOMEDICINE: Study of Interactions Between Nanoparticles Activated by External Electromagnetic Energy Sources and Cancer Cells forEnhancement of the Therapeutic Window
type: Dataset
description: The understanding of interactions between nanomaterials and biological entities is fundamental to develop nanoproducts in oncology. NBTXR3 (hafnium oxide inert nanoparticle) and protoporphyrin IX (Pp IX) nanocarrier (silica nanoparticle encapsulating Pp IX, the monomer of Photofrin®) are nanoproducts, issued from Nanobiotix platforms, aim to enlarge the therapeutic window of oncology treatment, using external energy sources to carry out "on" / "off" activation. In the first part of this work, we have studied interaction between NBTXR3 and human colon cancer cells. NBTXR3 penetrates by endocytosis and presents long residence within endo-lysosomal compartment. Significantly enhance of tumour cell radiation response is demonstrated after NBTXR3 activation with ionizing radiation. Compared to controls, irradiated cells having internalized NBTXR3, offer a particular morphology which is described. In the second part, we present the synthesis of a new hybrid nanoproduct for photodynamic therapy (PDT), the Pp IX nanocarrier, and the study of its interaction in vitro on six human cancer cell lines and in vivo on nude mice model xenografted with three different cancer types. In vitro, Pp IX nanocarrier activated at 630 nm is more efficient than free Pp IX. Further, this new hybrid nanoproduct enhances biodistribution of Pp IX, with different kinetic of tumour accumulation between models. Ultimately, based on these new understanding of interactions between nanoparticles and cancer cells, both NBTXR3 nanoparticle and Pp IX nanocarrier, offer a breakthrough approach to create efficient pathways to cancer therapy.
issued: 2026-05-10T19:46:30.769991
language: en
modified: 2026-05-10T19:46:30.769996
contact point: Organization
  fn: CCSD
keyword: biodistribution
keyword: cancer
keyword: cell-trafficking
keyword: cellules-tumorales
keyword: electromagnetic-energy-sources
keyword: endosome-residence
keyword: excitation-par-la-lumiere
keyword: fenetre-therapeutique
keyword: gold-nanoparticles
keyword: hafnium-oxide-nanoparticles
keyword: infoeu-reposemanticsdoctoralthesis
keyword: interaction-des-nanoparticules
keyword: ionizing-radiation
keyword: light-excitation
keyword: nanomedecine
keyword: nanomedicine
keyword: nanoparticles
keyword: nanoparticles-interaction
keyword: nanoparticules
keyword: nanoparticules-de-silice-encapsulant-la-protoporphyrine-ix-pp-ix
keyword: nanoparticules-dor
keyword: nanoparticules-doxyde-dhafnium
keyword: persistance-dans-les-endosomes
keyword: pharmacocinetique
keyword: pharmacokinetic
keyword: photodynamic-therapy-pdt
keyword: photofrin
keyword: photosensibilisant
keyword: photosensitizer
keyword: pp-ix-nanocarriers
keyword: pp-ix-nanotransporteur
keyword: protoporphyrin-ix-pp-ix-silica-nanoparticles
keyword: radiation-ionisante
keyword: radiotherapie
keyword: radiotherapy
keyword: sdvlife-sciences-q-bio
keyword: sources-denergie-electromagnetique
keyword: therapeutic-window
keyword: therapie-photodynamique
keyword: theses
keyword: trafic-cellulaire
keyword: tumour-cells
landing page: https://theses.hal.science/tel-00831605

ONCOLOGY NANOMEDICINE: Study of Interactions Between Nanoparticles Activated by External Electromagnetic Energy Sources and Cancer Cells forEnhancement of the Therapeutic Window
type: Distribution
format: HTML
issued: 2026-05-10T19:46:30.790444
modified: 2026-05-10T19:46:30.731346
access URL: https://theses.hal.science/tel-00831605

test_moissonnage_selune
type: Agent