Chitosan bi-layered physical hydrogels for in vivo wound healing after third degree burn
type: Dataset
description: This work deals with the study of the biological properties of bi-layered chitosan physical hydrogels within the context of third degree burns healing. These materials are elaborated thanks to the combination of two different gelification processes, without the use of any kind of chemical cross-linking agent. Chitosan physical hydrogels exhibit interesting antibacterial properties towards Gram+ and Gram- bacteria. Long term healing study shows that the use of physical hydrogels lead to a well-organized and well-vascularised regenerated skin, whose mechanical and aesthetic properties are similar to those of native skin. The main clinical benefit of this device is that it could be maintained during the all healing time, so as to prevent the risk of infection, the pain and the damages of neo-formed tissues. Skin has been studied with several approaches, namely aesthetic, clinical, mechanical, histological, immunohistological, and nanostructural (Small Angle X-ray Scattering) approaches. The detailed histological investigations confirm bi-layered hydrogels bioactivity and cellularizability: such devices can be considered as favourable media for tissue engineering.
identifier: NNT: 2011LYO10078
issued: 2026-05-10T20:28:03.838973
language: fr
modified: 2026-05-10T20:28:03.838978
contact point: Organization
  fn: CCSD
keyword: biomaterial
keyword: biomateriaux
keyword: brulures
keyword: burns
keyword: chitosan
keyword: chitosane
keyword: cicatrisation
keyword: hydrogel
keyword: infoeu-reposemanticsdoctoralthesis
keyword: sdvmheplife-sciences-q-biohuman-health-and-pathology
keyword: skin
keyword: theses
keyword: tissu-cutane
keyword: wound-healing
landing page: https://theses.hal.science/tel-00830801

Chitosan bi-layered physical hydrogels for in vivo wound healing after third degree burn
type: Distribution
format: HTML
issued: 2026-05-10T20:28:03.842809
modified: 2026-05-10T20:28:03.820672
access URL: https://theses.hal.science/tel-00830801

test_moissonnage_selune
type: Agent