Multiparticulate colon drug delivery systems
type: Dataset
description: Crohn's disease and ulcerative colitis are two related but distinct chronic inflammatory disorders of gastrointestinal tract (GIT), commonly denoted as inflammatory bowel disease(IBD). The main goal of the anti-inflammatory treatment of this disorder is to achieve maximal drug concentration in inflamed area and reduce systemic adverse effects. For this purpose several colon-spécifie drug delivery systems have been investigated. In addition, the design of pellets as oral drug delivery systems may provide many advantages over single unit preparations and thus improve patient compliance. It is well known that most existing treatments of IBD are associated with significant side effects and for this reason the formulation with a " food like " composition was designed. In the first part of our study, therapeutic efficiency of rutin/chitosan pellets with coatings based on natural polysaccharides degraded by colonie microbiota compared to commercialized 5-aminosalicylic acid (5-ASA) pellets was investigated. Release profiles ofcoated pellets showed a minimal drug release in simulated stomach and small intestine following by rapid drug release upon exposure to the colonie fluid. The results from in vivo testing showed that rutin attenuated efficiently inflammation in the colon and coated pellets were as effective as 5-ASA pellets in mitigating experimental colitis. The studies demonstrated that rutin administration via chitosan core coated pellets seems to be apromising approach for colon-specific delivery since they could interact easily with the mucin layer and deliver drug especially to the inflamed colonie area to relieve symptoms of IBD omitting side effects related to conventional treatment. The second objective of this thesis was to explore the impact of additional mucoadhesive polymer chitosan in the pellets core on the therapeutic efficiency. For this purpose, 5-ASA loaded pellets were produced by extrusion/spheronisation method and subsequently coated with pH-sensi…
identifier: NNT: 2012BESA3009
issued: 2026-05-10T20:41:28.158507
language: fr
modified: 2026-05-10T20:41:28.158512
contact point: Organization
  fn: CCSD
keyword: 5-aminosalicyclic-acid-in-vitro-characterisings
keyword: 5-asa-5-aminosalicylique
keyword: chitosan
keyword: colon-drug-delivery
keyword: inflammatory-bowel-disease
keyword: infoeu-reposemanticsdoctoralthesis
keyword: mici-maladies-inflammatoires-chroniques-de-lintestin
keyword: pellets
keyword: rutin
keyword: sdvmheplife-sciences-q-biohuman-health-and-pathology
keyword: theses
landing page: https://theses.hal.science/tel-00830507

Multiparticulate colon drug delivery systems
type: Distribution
format: HTML
issued: 2026-05-10T20:41:28.178863
modified: 2026-05-10T20:41:28.143989
access URL: https://theses.hal.science/tel-00830507

test_moissonnage_selune
type: Agent