Statistical inference in logistic regression model with immune fraction
Generalized linear models are a generalization of linear regression models, and are widely used in the field of life. The logistic regression model, one of this class of models, widely used in biomedical studies remains the most appropriate regression model when it comes to model discrete variable, binary in nature. In this thesis, we investigate the problem of statistical inference in the logistic regression model, in the presence of immune individuals in the study population.At first, we consider the problem of estimation in the logistic regression model in the presence of immune individuals that enters in the case of zero-inflated regression models. A subject is said to be immune if he cannot experience the outcome of interest. The immune status is unknown unless the event of interest has been observed. We develop a maximum like lihood estimation procedure for this problem, based on the joint modeling of the binary response of interest and the cure status. We investigate the identifiability of the resulting model. Then, we establish the existence, consistency and asymptotic normality of the proposed estimator, and we conduct a simulation study to investigate its finite-sample behavior. In a second time, we focus on the construction of simultaneous confidence bands for the probability of infection in the logistic regression model with immune fraction.We propose three methods of construction of confidence bands for the regression function. The first method (Scheffe's method) uses the asymptotic normality of the maximum like lihood estimator, and an approximation by the chi-squared distribution to approximate the necessary quantile for the construction of bands. The second method uses also the asymptotic normality of the maximum like lihood estimator and is based on a classical equality by (Landau & Sheep 1970). The third method (bootstrap method) is based on simulations, to estimate the appropriate quantile of the law of a supremum of a Gaussian process. Finally, we conduct a simulation study to investigate its finite-sample properties.Finally, we consider a study of dengue fever, which is a tropical mosquito-borneviral human disease, strictly inter-human. The results show that, the estimated probabilities of infection obtained from our approach are larger than the ones derived from a standard analysis that does not take account of the possible immunity. Inparticular, the estimates provided by our approach suggest that underweight constitutes a major risk factor for dengue infection, irrespectively of age.