CTG expansion and early proliferative arrest of DM1 myoblastes
type: Dataset
description: Myotonic Dystrophy type I is the most common neuromuscular pathology at adult age. DM1 is characterized by a multisystemic but variable phenotype, correlated with the size of the CTG expansion. Skeletal muscle tissue is particularly affected showing myotonic symptoms and atrophy. Myoblasts, responsible for skeletal muscle growth and repair, present in DM1 patients a reduced proliferative capacity compared to cells isolated from non-affected individuals. During a previous study, p16INK4A was identified as the trigger of this abnormal proliferative arrest in DM1 myoblasts, but mechanisms activating this pathway are still unknown. In this study, we attempted to decrypt these mechanisms, particularly the potential links between CTG expansions, oxidative stress sensitivity and early activation of the p16 pathway leading to myoblasts senescence
landing page: https://theses.hal.science/tel-00829312
identifier: NNT: 2012PAO66195
keyword: capacite-proliferative
keyword: dystrophie
keyword: dystrophy
keyword: expansions
keyword: infoeu-reposemanticsdoctoralthesis
keyword: myoblastes
keyword: myoblasts
keyword: oxydative-stress
keyword: p16
keyword: proliferative-capacity
keyword: sdvbbmlife-sciences-q-biobiochemistry-molecular-biology
keyword: stress-oxydatif
keyword: theses
issued: 2026-05-10T21:48:08.143949
modified: 2026-05-10T21:48:08.143953
language: fr
contact point: Organization
  fn: CCSD

test_moissonnage_selune
type: Agent

CTG expansion and early proliferative arrest of DM1 myoblastes
type: Distribution
format: HTML
access URL: https://theses.hal.science/tel-00829312
issued: 2026-05-10T21:48:08.162109
modified: 2026-05-10T21:48:08.123684