Intrauterine growth restriction and vulnerability to the metabolic syndrome : research of placental markers by proteomic analysis in rats and experimental and clinical evaluation
type: Dataset
description: Growing evidences indicate that a small birthweight, resulting from maternal malnutrition or others prenatal alterations, is associated with an increased neonatal morbidity and mortality and may lead to higher propensity to develop a metabolic syndrome (including type 2 diabetes, obesity, hypertension and dyslipidemia) in adulthood. However, the physiopathological mechanisms acting in utero on the programming of the offspring's metabolic profile remain confused and may implicate numerous molecules and physiological systems. Several data suggest that the placental alterations may have long-lasting consequences and could thus contribute to the programming of adult metabolic diseases. The placenta is the primary means of communication and nutrient delivery to the fetus and is also involved in fetal homeostasis. Thus, the placenta may constitute an appropriate organ for investigating how differences in maternal food consumption are sensed by the fetus along the pregnancy. Because of the increasing proportion of women eating inadequately during pregnancy and because such nutritional disturbances may have huge repercussions on adult health of the offspring, we urgently have to better understand how the placenta elaborates adaptive responses to maternal food intake modulations. My PhD aimed at identifying new placental pathways implicated in fetal growth restriction in rat, and investigated in human placental samples, the expression of these factors in pregnancies with fetal growth disturbances.As maternal malnutrition constitutes an important part in the etiology of intrauterine growth restriction (IUGR), we used an experimental model performed in rats which consists of a reduction (from 50% to 70%) of the daily maternal food intake during the gestation. These regimens lead to profound growth disturbances of the feto-placental unit revealed by drastic reductions of both placental and birth weights at term. To identify new placental pathways implicated in IUGR, we have use…
identifier: NNT: 2011LIL2S040
issued: 2026-05-10T22:01:28.163344
language: fr
modified: 2026-05-10T22:01:28.163348
contact point: Organization
  fn: CCSD
keyword: bdnf
keyword: croissance-ftale
keyword: fetal-growth
keyword: infoeu-reposemanticsdoctoralthesis
keyword: modele-murin
keyword: rciu
keyword: sdvmheplife-sciences-q-biohuman-health-and-pathology
keyword: theses
landing page: https://theses.hal.science/tel-00829097

Intrauterine growth restriction and vulnerability to the metabolic syndrome : research of placental markers by proteomic analysis in rats and experimental and clinical evaluation
type: Distribution
format: HTML
issued: 2026-05-10T22:01:28.165550
modified: 2026-05-10T22:01:28.151275
access URL: https://theses.hal.science/tel-00829097

test_moissonnage_selune
type: Agent