Long term modifications of noradrenergic and serotonergic systems in the behavioral sensitization induced by amphetamine and serotonine
type: Dataset
description: Our team studies the neurobiological changes induced by drugs of abuse through the behavioral sensitization model. This model is characterised, in rodents, by a progressively enhanced locomotor response to repeated exposures to drugs of abuse. We have previously shown that the behavioral sensitization to main classes of drugs of abuse (psychostimulants, opiates, alcohol or tobacco) observed in C57Bl/6J mice was underlined by a noradrenergic and a serotonergic neuronal sensitization. In my thesis, I first detail the pathway followed by ethanol to induce a noradrenergic neuronal sensitization. Our data have shown that the µ-opioid system is essential to induce this phenomenon. Actually, the blockade by naltrexone of µ-opioid receptors before ethanol injections prevents the development of ethanol behavioral sensitization. Moreover, µ-opioid receptors knock-out mice did not exhibit behavioral nor noradrenergic sensitization to ethanol although they were still responsive to sensitization induced by amphetamine. Secondly, we studied how the noradrenergic and serotonergic sensitization induced by amphetamine could persist after many months withdrawal. Electrophysiological recordings as well as micro-dialysis experiments showed that noradrenergic and serotonergic inhibitor feedbacks, composed by α2A-adrenergic and 5-HT1A auto-receptors respectively, were persistently impaired in rats and mice sensitized to amphetamine. This desensitization was correlated with a decreased expression of Gαi proteins coupled to these receptors.
landing page: https://theses.hal.science/tel-00828603
identifier: NNT: 2012PA066385
keyword: addiction
keyword: amphetamine
keyword: ethanol
keyword: infoeu-reposemanticsdoctoralthesis
keyword: noradrenaline
keyword: sdvneunblife-sciences-q-bioneurons-and-cognition-q-bioncneurobiology
keyword: sensibilisation-comportementale
keyword: serotonine
keyword: theses
issued: 2026-05-10T22:28:37.935816
modified: 2026-05-10T22:28:37.935820
language: fr
contact point: Organization
  fn: CCSD

test_moissonnage_selune
type: Agent

Long term modifications of noradrenergic and serotonergic systems in the behavioral sensitization induced by amphetamine and serotonine
type: Distribution
format: HTML
access URL: https://theses.hal.science/tel-00828603
issued: 2026-05-10T22:28:37.938027
modified: 2026-05-10T22:28:37.923536