@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00828183v1> a dcat:Dataset ;
    dct:description """
              Obesity is a chronic low-grade inflammatory condition, with increased inflammatory mediators in the circulation and adipose tissue. Following up obese subjects before and after bariatric surgery, we observed a biphasic regulation of pro-inflammatory factors in circulation, showing drastic decreases at month 3 post-surgery followed by a rebound and stabilization after 1 year. Patient's nutritional status was a major determinant of this unexpected profile. In obese subjects, we found enrichment in "non-classical" CD14dimCD16+ circulating monocytes that was reduced after bariatric surgery. The pathogenicity of this particular subset in relation with low-grade inflammation remains to be established. Although obese adipose tissue is a site of immune cell infiltration in obesity, little is known about cross-talk between these cell types. We show that adipose tissue macrophages secrete IL-1β through NLRP3 inflammasome activation. This process was down-regulated by weight loss but overactivated in type 2 diabetic (T2D) patients. We also showed that the adipose tissue of obese T2D subjects is enriched in IL-17+IFN-β+ double producer lymphocytes. In primary cell co-culture experiments, adipose tissue macrophage-derived IL-1β enhanced IL-17 production by adipose tissue lymphocytes, while IL-17 reciprocally induced IL-1β secretion. T2D might exacerbate this cross-talk, as suggested by overexpression of each cytokine cognate receptor on their respective target cell. This identified IL-1β and IL-17 as two key cytokines mediating a new inflammatory cross-talk between adipose tissue macrophages and lymphocytes that might contribute to the deterioration of glycemic status in human obesity
            """ ;
    dct:identifier "NNT: 2012PAO66173" ;
    dct:issued "2026-05-10T22:49:40.857891"^^xsd:dateTime ;
    dct:language "en" ;
    dct:modified "2026-05-10T22:49:40.857895"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Adipose tissue inflammation in obesity and during surgery induced-weight loss : emerging paracrine dialogue between macrophages and lymphocytes" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00828183v1/resource/fa0a07be-ae5e-467c-9acc-2ec460ac1e5f> ;
    dcat:keyword "cellules-immunitaires",
        "diabete-de-type-2",
        "inflammasome",
        "inflammation",
        "infoeu-reposemanticsdoctoralthesis",
        "obesite",
        "sdvmhepphylife-sciences-q-biohuman-health-and-pathologytissues-and-organs-q-bioto",
        "theses",
        "tissu-adipeux" ;
    dcat:landingPage <https://theses.hal.science/tel-00828183> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00828183v1/resource/fa0a07be-ae5e-467c-9acc-2ec460ac1e5f> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-10T22:49:40.872320"^^xsd:dateTime ;
    dct:modified "2026-05-10T22:49:40.845916"^^xsd:dateTime ;
    dct:title "Adipose tissue inflammation in obesity and during surgery induced-weight loss : emerging paracrine dialogue between macrophages and lymphocytes" ;
    dcat:accessURL <https://theses.hal.science/tel-00828183> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .

<https://theses.hal.science/tel-00828183> a foaf:Document .