Adipose tissue inflammation in obesity and during surgery induced-weight loss : emerging paracrine dialogue between macrophages and lymphocytes
type: Dataset
description: Obesity is a chronic low-grade inflammatory condition, with increased inflammatory mediators in the circulation and adipose tissue. Following up obese subjects before and after bariatric surgery, we observed a biphasic regulation of pro-inflammatory factors in circulation, showing drastic decreases at month 3 post-surgery followed by a rebound and stabilization after 1 year. Patient's nutritional status was a major determinant of this unexpected profile. In obese subjects, we found enrichment in "non-classical" CD14dimCD16+ circulating monocytes that was reduced after bariatric surgery. The pathogenicity of this particular subset in relation with low-grade inflammation remains to be established. Although obese adipose tissue is a site of immune cell infiltration in obesity, little is known about cross-talk between these cell types. We show that adipose tissue macrophages secrete IL-1β through NLRP3 inflammasome activation. This process was down-regulated by weight loss but overactivated in type 2 diabetic (T2D) patients. We also showed that the adipose tissue of obese T2D subjects is enriched in IL-17+IFN-β+ double producer lymphocytes. In primary cell co-culture experiments, adipose tissue macrophage-derived IL-1β enhanced IL-17 production by adipose tissue lymphocytes, while IL-17 reciprocally induced IL-1β secretion. T2D might exacerbate this cross-talk, as suggested by overexpression of each cytokine cognate receptor on their respective target cell. This identified IL-1β and IL-17 as two key cytokines mediating a new inflammatory cross-talk between adipose tissue macrophages and lymphocytes that might contribute to the deterioration of glycemic status in human obesity
identifier: NNT: 2012PAO66173
issued: 2026-05-10T22:49:40.857891
language: en
modified: 2026-05-10T22:49:40.857895
contact point: Organization
  fn: CCSD
keyword: cellules-immunitaires
keyword: diabete-de-type-2
keyword: inflammasome
keyword: inflammation
keyword: infoeu-reposemanticsdoctoralthesis
keyword: obesite
keyword: sdvmhepphylife-sciences-q-biohuman-health-and-pathologytissues-and-organs-q-bioto
keyword: theses
keyword: tissu-adipeux
landing page: https://theses.hal.science/tel-00828183

Adipose tissue inflammation in obesity and during surgery induced-weight loss : emerging paracrine dialogue between macrophages and lymphocytes
type: Distribution
format: HTML
issued: 2026-05-10T22:49:40.872320
modified: 2026-05-10T22:49:40.845916
access URL: https://theses.hal.science/tel-00828183

test_moissonnage_selune
type: Agent