Molecular and signaling mechanisms induced by oxidative stress in a Drosophila in vivo model of Parkinson's disease : paraquat intoxication and alpha-synuclein expression
type: Dataset
description: Parkinson's disease (PD) is well characterized as a neurodegenerative disease with progressive loss of dopaminergic neurons (DAn) from substantia nigra, a subcortical structure of the basal ganglia. Most of time, PD is sporadic but it is known that exposure to environmental toxins like pesticides or mutations of genes like -synuclein can cause PD. -syncuclein is the main component of Lewy's bodies, which are cytoplasmic inclusions present in DAn in PD. During my Ph.D., I focused first on the study of paraquat (PQ) neurotoxicity, a strong oxidative stress generator involved in PD. Our results show that PQ toxicity can be triggered by dopamine signaling trough a D1-like dopamine receptor known mainly for its involvement in memory processes in Drosophila. Inactivation of this receptor in glutamatergic neurons was found to be protective against PQ toxicity in Drosophila. Later, I focused on the study of a-synuclein neurotoxicity and its relationship with oxidative stress. This led to the development of a whole Drosophila central nervous system explants culture technique that allowed study of a-synuclein effects on vesicular dynamic along the axons of DAn through FRAP experiments. This study led to a better understanding of the relationships between DA and oxidative stress in the PD's pathogenesis
identifier: NNT: 2012PAO66556
issued: 2026-05-10T23:06:54.837829
language: fr
modified: 2026-05-10T23:06:54.837834
contact point: Organization
  fn: CCSD
keyword: alpha-synuclein
keyword: alpha-synucleine
keyword: central-nervous-system
keyword: drosophila
keyword: infoeu-reposemanticsdoctoralthesis
keyword: maladie-de-parkinson
keyword: oxidative-stress
keyword: paraquat
keyword: parkinsons-disease
keyword: scconeurcognitive-scienceneuroscience
keyword: stress-oxidatif
keyword: systeme-nerveux-central
keyword: theses
landing page: https://theses.hal.science/tel-00827809

Molecular and signaling mechanisms induced by oxidative stress in a Drosophila in vivo model of Parkinson's disease : paraquat intoxication and alpha-synuclein expression
type: Distribution
format: HTML
issued: 2026-05-10T23:06:54.840415
modified: 2026-05-10T23:06:54.822378
access URL: https://theses.hal.science/tel-00827809

test_moissonnage_selune
type: Agent