@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00827746v1> a dcat:Dataset ;
    dct:description """
              Caveolin-1 and cavins proteins form membrane caveolae, invaginations of the plasma membrane that are particularly abundant adipocytes and endothelial cells within adipose tissue. Caveolin-1 deficiency leads to lipoatrophy in transgenic mice models suggesting a critical role in the control of lipid storage. Studies on Cav-1 deficient mice model (Cav1 (-/-) mice) also revealed important defects in the cardiovascular function, that are rescued by specific reexpression of Cav1 in endothelium (Cav1 RC mice).To address the contribution of endothelial caveolin-1 expression to the lipoatrophic phenotype, we compared metabolic phenotypes observed in Cav1 deficient with those of Cav1 RC and control mice and found a persistent lipoatrophic phenotype in Cav1 (-/-) mice. Considering the key role of caveolin-1 in the control of adipose tissue lipid storage capacity, we chose an overexpression approach of caveolin-1 and cavins 3T3-L1 adipocytes to investigate the underlying molecular mechanisms. All three cell lines contained a higher number of caveolae whereas only caveolin-1 overexpression led to lipid droplet expansion both in vitro and in vivo, suggesting that caveolin-1 control on lipid storage occurs outside of caveolae. In agreement, larger lipid droplets were found in cells expressing a caveolin-1-perilipin-GFP fusion construct, in which exogenous caveolin-1 strictly localized onto lipid droplets. Together our data demonstrate a specific role of lipid droplet caveolin-1 pool, independent of caveolae to modulate lipid droplet expansibility
            """ ;
    dct:identifier "NNT: 2012PA066071" ;
    dct:issued "2026-05-10T23:10:50.028311"^^xsd:dateTime ;
    dct:language "fr" ;
    dct:modified "2026-05-10T23:10:50.028316"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Role of caveolin-1 in control of adipocyte lipid storage capacties" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00827746v1/resource/c791ddfb-baa9-43cf-a5fe-9a21e76b0eb0> ;
    dcat:keyword "adipocyte",
        "caveole",
        "caveoline-1",
        "endothelium",
        "gouttelette-lipidique",
        "infoeu-reposemanticsdoctoralthesis",
        "sdvmhepphylife-sciences-q-biohuman-health-and-pathologytissues-and-organs-q-bioto",
        "stockage-lipidique",
        "theses" ;
    dcat:landingPage <https://theses.hal.science/tel-00827746> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00827746v1/resource/c791ddfb-baa9-43cf-a5fe-9a21e76b0eb0> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-10T23:10:50.041702"^^xsd:dateTime ;
    dct:modified "2026-05-10T23:10:50.017398"^^xsd:dateTime ;
    dct:title "Role of caveolin-1 in control of adipocyte lipid storage capacties" ;
    dcat:accessURL <https://theses.hal.science/tel-00827746> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .

<https://theses.hal.science/tel-00827746> a foaf:Document .