@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00827710v1> a dcat:Dataset ;
    dct:description """
              CD8+ T cell responses are crucial in the defense against several infectious agents, as well as for the treatment of cancer. Thus, the development of vaccine strategies capable of eliciting robust CD8+ T cell responses is needed. Antigen cross-presentation is known to be an important mechanism for the activation of antigen-specific CD8+ T cells, and multiple parameters contribute to the efficiency of cross-priming. We examined two of them : the route of immunization and the timing of adjuvant delivery. First, we developed the tetramer-based enrichment strategy, which allowed us to study the endogenous CD8+ T cell response. Then, we investigated the impact of the route of immunization on CD8+ T cell cross-priming. We report that local delivery of cell-associated antigen results in delayed cross-priming due to the increased time required for antigen capture and presentation. In comparison, delivery of systemically disseminated antigen resulted in rapid T cell priming. Surprisingly, local injection of cell-associated antigen, while slower to mount a functional response, resulted in the differentiation of a more robust effector T cell population. We were next interested in evaluating the combination of cell-associated antigen with the delivery of poly I:C, an adjuvant known to induce the production of type I interferons (IFN). We observed an immunization-route-specific effect regarding the timing of innate immune stimulation and identified the optimal time window for adjuvant administration in order to maximize the boosting effects on CD8+ T cell cross-priming. We characterized in detail several effects of poly I:C, as well as type I IFN, exerted on immune cells
            """ ;
    dct:identifier "NNT: 2012PAO66152" ;
    dct:issued "2026-05-10T23:14:08.930637"^^xsd:dateTime ;
    dct:language "en" ;
    dct:modified "2026-05-10T23:14:08.930643"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Route of immunization and timing for adjuvant delivery : critical factors for efficient T cell cross-priming" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00827710v1/resource/97467727-b195-45ac-876f-e2c9df552cc3> ;
    dcat:keyword "adjuvant",
        "antigene-cellulaire",
        "cd8",
        "infoeu-reposemanticsdoctoralthesis",
        "interferons-de-type-i",
        "lymphocyte-t",
        "presentation-croisee",
        "sdvimmlife-sciences-q-bioimmunology",
        "theses",
        "vaccination" ;
    dcat:landingPage <https://theses.hal.science/tel-00827710> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00827710v1/resource/97467727-b195-45ac-876f-e2c9df552cc3> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-10T23:14:08.935889"^^xsd:dateTime ;
    dct:modified "2026-05-10T23:14:08.918411"^^xsd:dateTime ;
    dct:title "Route of immunization and timing for adjuvant delivery : critical factors for efficient T cell cross-priming" ;
    dcat:accessURL <https://theses.hal.science/tel-00827710> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .

<https://theses.hal.science/tel-00827710> a foaf:Document .