@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00820033v1> a dcat:Dataset ;
    dct:description """
              One of the chemically most challenging problems in enzymology is the functionalization of non-reactive C–H bonds. Such reactions require specialized cofactors as heme, Fe-µ-oxo or vitamin B12. In 2001, special Fe-S centers able to bind S-Adenosylmethionine (SAM) have been shown to activate non-reactive C-H bonds toward subsequent functionalization. Enzymes containing this new cofactor constitute a super-family called “Radical SAM”. Methylthiotransferases (MTTases) belong to the “Radical SAM” super-family and catalyse the insertion of a methylthio group (-SCH3) in C-H bonds. By doing in vitro and in vivo experiments, we were able to classify them into three groups. The first class, (RimO) catalyses the formation of β-methylthio-aspartate 89 on the ribosomal protein S12 (β-ms-D89-S12) whereas the two others (MiaB and MtaB/eMtaB) respectively catalyse the thiomethylation of the nucleosides 2-methylthio-N6-isopentenyladenosine 37 (ms2i6A-37) and 2-methylthio-N6-threoninecarbamoyl adenosine 37 (ms2t6A-37) present in some tRNA. Our studies have shown that, in vitro, MTTases catalyse the insertion of a SCH3 group in a catalytic way suggesting entirely new radical sulfur insertion mechanisms.
            """ ;
    dct:identifier "NNT: 2011GRENV048" ;
    dct:issued "2026-05-11T05:50:16.541231"^^xsd:dateTime ;
    dct:language "fr" ;
    dct:modified "2026-05-11T05:50:16.541236"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Biological radical sulfur insertion. A study of methylthiotransferases." ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00820033v1/resource/81196dc7-c99d-4517-b3a5-d35e235217e4> ;
    dcat:keyword "cdkal1",
        "infoeu-reposemanticsdoctoralthesis",
        "methylthiotransferases",
        "miab",
        "mtab",
        "radical-sam",
        "rimo",
        "sdvotlife-sciences-q-bioother-q-bioot",
        "theses" ;
    dcat:landingPage <https://theses.hal.science/tel-00820033> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00820033v1/resource/81196dc7-c99d-4517-b3a5-d35e235217e4> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-11T05:50:16.557040"^^xsd:dateTime ;
    dct:modified "2026-05-11T05:50:16.531193"^^xsd:dateTime ;
    dct:title "Biological radical sulfur insertion. A study of methylthiotransferases." ;
    dcat:accessURL <https://theses.hal.science/tel-00820033> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .

<https://theses.hal.science/tel-00820033> a foaf:Document .