Participation of nutritional and environmental factors in aging of the retina and age-related retinopathies
type: Distribution
access URL: https://theses.hal.science/tel-00818990
format: HTML
issued: 2026-05-11T06:49:37.821624
modified: 2026-05-11T06:49:37.802193

test_moissonnage_selune
type: Agent

Participation of nutritional and environmental factors in aging of the retina and age-related retinopathies
type: Dataset
contact point: Organization
  fn: CCSD
keyword: retinopathie
keyword: produits-terminaux-de-glycation
keyword: theses
keyword: omega-3
keyword: infoeu-reposemanticsdoctoralthesis
keyword: nutrition
keyword: vieillissement
keyword: lipide
keyword: stress-oxydatif
keyword: no-english-keyword
keyword: sdvmheplife-sciences-q-biohuman-health-and-pathology
keyword: retine
keyword: prevention
landing page: https://theses.hal.science/tel-00818990
description: With advanced age, aging of the human retina can evolve into pathological forms, age-related macular degeneration (AMD) or diabetic retinopathy (DR). Meanwhile, epidemiological studies suggest that a diet rich in long-chain omega-3 polyunsaturated fatty acids (LC-PUFA) such as EPA and DHA, potentially protects against the development of AMD and insulin resistance, the main risk factor for DR. Within this context, our research objectives were to assess: 1 - the impact of endogen and environmental factors, known to trigger oxidative stress, advanced glycation end-products (AGEs) or insulin resistance, on the function and aging of the retina, and 2 - the response of the retina to a omega-3 LC-PUFA-enriched diet in a murine model of aging of the human retina, the ApoB100,LDLR-/- mouse.The animals exposed to oxidative stress and AGEs showed an alteration of the retinal function associated with an accumulation of microglial cells and/or macrophages in the outer retina. The insulin resistance induced a modulation of the expression of genes coding proteins involved in lipid metabolism, inflammation and nuclear factors. An omega-3 LC-PUFA-enriched diet improved the incorporation of omega-3 LC-PUFA in the retina and modulated the expression of the LDL-receptor gene in the neurosensory retina.In conclusion, our works reported the adaptive response of the retina to environmental and endogenous factors known to promote aging of the retina. It included the impairment of the retinal function, and the modulation of gene expression. Our data also gave a better understanding of the effects of omega-3 LC-PUFA against aging of the retina
identifier: NNT: 2012DIJOS028
issued: 2026-05-11T06:49:37.817219
language: fr
modified: 2026-05-11T06:49:37.817224