Nanodiamonds surface modifications : understanding of electron exchange mecanisms and evidence of a therapeutic effect
type: Dataset
description: In this thesis, a therapeutic effect of nanodiamonds (NDs) has been evidenced by investigating the role of NDs surface chemistry on their electronic properties. More precisely, the generation of reactive oxygen species from detonation NDs under ionizing radiation, which could improve current radiotherapy treatments, has been demonstrated. To this end, surface treatments facilitating electron transfer from NDs to their environment, namely hydrogenation and surface graphitization, were developed. Experimental conditions ensuring an efficient hydrogenation by hydrogen plasma were determined under ultrahigh vacuum, before being used to prepare large quantities of NDs in powder phase. A similar procedure was applied to the surface graphitization of NDs, performed by annealing under vacuum at high temperature. The impact of such surface treatments on the electronic interaction properties of NDs has been investigated under ambient air and after dispersion in water. These surface treatments induce a positive Zeta potential to NDs in water, which origin has been discussed. Finally, their interactions with human tumor cells were observed. Radiosensitization of tumor cells using NDs under gamma irradiation was demonstrated, opening new perspectives for NDs in nanomedicine.
identifier: NNT: 2013DENS0010
issued: 2026-05-11T10:14:07.595325
language: fr
modified: 2026-05-11T10:14:07.595330
contact point: Organization
  fn: CCSD
keyword: chimie-de-surface
keyword: chimothechemical-sciencesother
keyword: electron-transfer
keyword: infoeu-reposemanticsdoctoralthesis
keyword: nanodiamant
keyword: nanodiamond
keyword: physcondcm-genphysics-physicscondensed-matter-cond-matother-cond-matother
keyword: potentiel-zeta
keyword: radiosensibilisation
keyword: radiosensitization
keyword: surface-chemistry
keyword: theses
keyword: transfert-electronique
keyword: zeta-potential
landing page: https://theses.hal.science/tel-00815281

Nanodiamonds surface modifications : understanding of electron exchange mecanisms and evidence of a therapeutic effect
type: Distribution
format: HTML
issued: 2026-05-11T10:14:07.599970
modified: 2026-05-11T10:14:07.575854
access URL: https://theses.hal.science/tel-00815281

test_moissonnage_selune
type: Agent