lnvolvement of the ventral hippocampus and reuniens and rhomboid thalamic nuclei in cognitive processes underlying spatial memory in rats
type: Dataset
description: The main objective of this thesis was to investigate the role of the ventral hippocampus (HPC) and the reuniens (Re) and rhomboid (Rh) thalamic nuclei in the cognitive processes underlying spatial memory in the Rat. If our results first confirmed, in the Morris water maze, the role of the dorsal HPC in the acquisition and retrieval of a spatial reference memory, we demonstrated the specific involvement of the ventral HPC only in the recall of spatial information. In addition, by using complementary approaches combining brain imaging, excitotoxic lesion and reversible functional inactivation, we were able to show for the first time a key role for the Re and Rh in the persistence of a spatial memory (25 days). Finally, the third set of experiments has highlighted the involvement of the Re and Rh in a mnemonic task performed in a new test, the double-H maze, which requires the use of spatial information depending on the integrity of the dorsal HPC, and a behavioral flexibility, involving the medial prefrontal cortex. Thus, taken together, these results suggest the involvement of a HPC-prefronto-thalamic network in various aspects of spatial information processing.
landing page: https://theses.hal.science/tel-00813293
identifier: NNT: 2012STRAJ082
keyword: excitotoxic-lesion
keyword: hippocampe-ventral
keyword: inactivation
keyword: infoeu-reposemanticsdoctoralthesis
keyword: lesion-excitotoxique
keyword: lidocaine
keyword: memoire-spatiale
keyword: noyau-reunien-du-thalamus
keyword: piscine-de-morris
keyword: rat
keyword: reuniens-and-rhomboid-thalamic-nuclei
keyword: sdvmheplife-sciences-q-biohuman-health-and-pathology
keyword: sdvneulife-sciences-q-bioneurons-and-cognition-q-bionc
keyword: spatial-memory
keyword: theses
keyword: ventral-hippocampus
issued: 2026-05-11T12:07:28.837293
modified: 2026-05-11T12:07:28.837300
language: fr
contact point: Organization
  fn: CCSD

test_moissonnage_selune
type: Agent

lnvolvement of the ventral hippocampus and reuniens and rhomboid thalamic nuclei in cognitive processes underlying spatial memory in rats
type: Distribution
format: HTML
access URL: https://theses.hal.science/tel-00813293
issued: 2026-05-11T12:07:28.840252
modified: 2026-05-11T12:07:28.803656