oai-hal-tel-00811965v1
type: Dataset
description: Endometrial carcinoma is the most common gynaecologic malignancy in industrialized countries. Mechanisms involved in endometrial carcinogenesis are not fully understood and the classic prognostic factors failed in some cases to predict clinical outcome. In the current study, we analysed the expression of metalloproteinases (MMP-2,- 7 and -9) and tissue inhibitors of metalloproteinases (TIMP-1 and -2) in normal endometrium, endometrial hyperplasia and endometrial cancer. Our results support the involvement of MMPs and TIMPs in endometrial carcinogenesis. Strong MMP-2 and weak TIMP-2 expression were potent markers of endometrial aggressiveness with a high risk of local and distant spread. TP53 loss of heterozygosity (LOH) was preferentially detected in serous endometrial carcinomas and in high-grade endometrioid carcinomas suggesting that different pathways may be involved in endometrial carcinogenesis. In endometrial cancer, TP53 FISH does not appear to add significant prognostic data compared with routine immunohistochemistry. Finally, histopronostic correlations established in this work suggest that concomitant evaluation of the expression of MMP-2, TIMP-2, ploidy, p53, Ki67 and oestrogen and progesterone receptors on specimens could select patients at high risk of local recurrence and distant spread.
identifier: NNT: 2008PA066310
issued: 2026-05-11T13:21:28.388021
language: fr
modified: 2026-05-11T13:21:28.388026
title: Expression of matrix-metalloproteinases (MMP-2, -7 and -9), tissue inhibitors of matrix-metalloproteinases (TIMP-1 and -2), apoptotic factors (P53 and Bcl-2) and steroid receptors (estrogen and progesterone receptors) in normal, hyperplastic and neoplastic endometrium : a clinical-pathological correlation study : fluorescence in situ hybridization and immunohistochemical analysis of P53 expression in endometrial cancer : prognostic value and relation to ploidy
contact point: Organization
  fn: CCSD
keyword: apoptose
keyword: apoptosis
keyword: cancer
keyword: cancer-de-lendometre
keyword: endometre
keyword: endometrium
keyword: hormonal-receptors
keyword: hyperplasia
keyword: hyperplasie-endometriale
keyword: infoeu-reposemanticsdoctoralthesis
keyword: inhibiteurs-tissulaires-des-metalloproteinases
keyword: metalloproteinases
keyword: p53
keyword: ploidie
keyword: ploidy
keyword: sdvmheplife-sciences-q-biohuman-health-and-pathology
keyword: theses
keyword: tissue-inhibitorof-metalloproteinases
landing page: https://theses.hal.science/tel-00811965

https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00811965v1/resource/92a73cbe-4b11-49c5-90c9-70f596f282ad
type: Distribution
format: HTML
issued: 2026-05-11T13:21:28.392508
modified: 2026-05-11T13:21:28.351674
title: Expression of matrix-metalloproteinases (MMP-2, -7 and -9), tissue inhibitors of matrix-metalloproteinases (TIMP-1 and -2), apoptotic factors (P53 and Bcl-2) and steroid receptors (estrogen and progesterone receptors) in normal, hyperplastic and neoplastic endometrium : a clinical-pathological correlation study : fluorescence in situ hybridization and immunohistochemical analysis of P53 expression in endometrial cancer : prognostic value and relation to ploidy
access URL: https://theses.hal.science/tel-00811965

test_moissonnage_selune
type: Agent