élaboration of new functionalized bacterial biopolyesters for biomedical applications
type: Dataset
description: Poly(3-hydroxyalkanoate)s, or PHAs, are linear biodegradable and biocompatible biopolyesters synthesized by bacterial microorganisms as energy and carbon supply. They are synthesized by bacteria from renewable resources and the diversity of the achievable structures leads to a large range of mechanical properties. First, we studied the PHAs production ability of several new marine bacteria strains, isolated from microbial mats from French Polynesia, using, among others, natural substrates such as coprah oil, glucose and oleic acid. We showed particularly that the strain Pseudomonas guezennei was able to produce PHAs with controlled amounts of insaturations and high molar masses. Then, we prepared functionalized PHAs oligomers with controlled structure and bearing a terminal alkyne or alkene function. Following that, these oligomers were used to elaborate amphiphilic by click chemistry graft copolymers EPS-g-PHA with bacterial exopolysaccharide (EPS). Finally, the last part of this work was the making of a scaffold for stem cell culture for tissue engineering which combined the mechanical properties of PHAs and the hydrophilicity and bioactive properties of EPS
landing page: https://theses.hal.science/tel-00804382
identifier: NNT: 2012PEST1143
keyword: amphiphilic-copolymer
keyword: bacterial-polyester
keyword: chimie-click
keyword: chimothechemical-sciencesother
keyword: click-chemistry
keyword: copolymere-amphiphile
keyword: exopolysaccharide
keyword: functionalized-oligoesters
keyword: infoeu-reposemanticsdoctoralthesis
keyword: oligoesters-fonctionnalises
keyword: poly3-hydroxyalcanoate
keyword: poly3-hydroxyalkanoate
keyword: polyester-bacterien
keyword: theses
issued: 2026-05-12T04:24:05.436736
modified: 2026-05-12T04:24:05.436741
language: fr
contact point: Organization
  fn: CCSD

test_moissonnage_selune
type: Agent

élaboration of new functionalized bacterial biopolyesters for biomedical applications
type: Distribution
format: HTML
access URL: https://theses.hal.science/tel-00804382
issued: 2026-05-12T04:24:05.521140
modified: 2026-05-12T04:24:05.407810