@prefix dcat: . @prefix dct: . @prefix foaf: . @prefix vcard: . @prefix xsd: . a dcat:Dataset ; dct:description """ The work performed during this PhD thesis aimed at investigating the role of the transcriptional silencer Rev-erbα in both the circadian clockwork of the food-entrainable oscillator and metabolic regulations. Firstly, by evaluating food-anticipatory components in animals fed once a day at the same time, we showed that mice lacking Rev-erbα display a reduction in locomotor activity prior to food access compared to littermate controls. Accordingly, the rises in body temperature and corticosterone that anticipate mealtime are also diminished. Interestingly, daily p-ERK expression in hypothalamic regions and daily PER2 expression in the cerebellum of Rev-erbα KO mice are not phase-adjusted to feeding time. These results indicate that Rev-erbα participates in the integration of feeding signals and in food-seeking behaviors. Secondly, by investigating energy balance in fasted, normal chow or high-fat fed animals, we revealed that Rev-erbα KO mice exhibit greater reliance on lipid fuels as energy substrates, contributing to a mild hyperglycemic state. We also found that Lipoprotein lipase (Lpl) expression, is strongly up-regulated in peripheral tissues of Rev-erbα KO mice, predisposing mice to obesity. In this regard, we uncovered a new molecular pathway that ties clock-driven Lpl expression to energy homeostasis. These findings highlight the significance of daily Rev-erbα oscillations to prevent the appearance of the metabolic syndrome.In conclusion, we provide evidence that REV-ERBα may be a part of the food-entrainable oscillator clockwork that triggers food-anticipatory components, and represents a pivotal player to link the core clock machinery to metabolic pathways. """ ; dct:identifier "NNT: 2012STRAJ018" ; dct:issued "2026-05-12T11:20:59.701136"^^xsd:dateTime ; dct:language "en" ; dct:modified "2026-05-12T11:20:59.701142"^^xsd:dateTime ; dct:publisher ; dct:title "Role of the nuclear receptor Rev-erb alpha in circadian food anticipation and metabolism" ; dcat:contactPoint [ a vcard:Organization ; vcard:fn "CCSD" ] ; dcat:distribution ; dcat:keyword "anticipation-de-lheure-des-repas", "clock-gene", "food-entrainable-oscillator", "gene-dhorloge", "horloge-alimentaire", "infoeu-reposemanticsdoctoralthesis", "lipid-metabolism", "lipoprotein-lipase", "lipoproteine-lipase", "metabolisme-lipidique-et-glucidique", "obesite", "obesity", "respiratory-quotient", "rev-erb-alpha", "sdvmheplife-sciences-q-biohuman-health-and-pathology", "sdvneunblife-sciences-q-bioneurons-and-cognition-q-bioncneurobiology", "theses" ; dcat:landingPage . a dcat:Distribution ; dct:format "HTML" ; dct:issued "2026-05-12T11:20:59.716373"^^xsd:dateTime ; dct:modified "2026-05-12T11:20:59.646221"^^xsd:dateTime ; dct:title "Role of the nuclear receptor Rev-erb alpha in circadian food anticipation and metabolism" ; dcat:accessURL . a foaf:Agent ; foaf:name "test_moissonnage_selune" . a foaf:Document .