test_moissonnage_selune
type: Agent

Analysis of intramembranal penetration mechanisms of glycoconjugated porphyrins used in photodynamic therapy of cancers : Modelization of specific and non specific interactions
type: Dataset
contact point: Organization
  fn: CCSD
keyword: therapie-photodynamique
keyword: lectin
keyword: fluorescence-spectroscopy
keyword: dls
keyword: physphysphys-bio-phphysics-physicsphysics-physicsbiological-physics-physicsbio-ph
keyword: spectrometrie-de-fluorescence
keyword: modeles-membranaires
keyword: glycodendrimeric-porphyrins
keyword: concanavalin-a
keyword: photodynamic-therapy
keyword: lectine
keyword: retinoblastome
keyword: qcmd
keyword: cholesterol
keyword: supported-planar-bilayer
keyword: monocouches
keyword: surface-tensiometry
keyword: theses
keyword: cell-membrane-models
keyword: bicouches-planes-supportees
keyword: infoeu-reposemanticsdoctoralthesis
keyword: porphyrines-glycodendrimeriques
keyword: monolayers
keyword: concanavaline-a
keyword: liposomes
keyword: retinoblastoma
keyword: sdvsppglife-sciences-q-biopharmaceutical-sciencesgalenic-pharmacology
keyword: tensiometrie-de-surface
landing page: https://theses.hal.science/tel-00800719
description: The complexity of biological membranes is the cause of artificial membrane models development as essential tools for understanding the mechanisms of interaction between drugs and cell membrane. This thesis focuses on the study of specific and non specific interactions between new glycoconjugated porphyrins used in photodynamic therapy (PDT) and retinoblastoma biomimetic membrane models (monolayers, supported planar bilayers and liposomes) expressing at their surface a mannose specific lectin. The main characterization techniques used in this study, are the Quartz Crystal Microbalance with Dissipation Monitoring (QCM-D) and Dynamic Light Scattering (DLS). Glycoconjugated porphyrins are proved as promising molecules which are able to interact in a non specific (passive penetration) and specific ways (Lectin-like receptors targeting) with retinoblastoma membrane models.
issued: 2026-05-12T18:17:28.272345
language: fr
modified: 2026-05-12T18:17:28.272351

Analysis of intramembranal penetration mechanisms of glycoconjugated porphyrins used in photodynamic therapy of cancers : Modelization of specific and non specific interactions
type: Distribution
access URL: https://theses.hal.science/tel-00800719
format: HTML
issued: 2026-05-12T18:17:28.331447
modified: 2026-05-12T18:17:28.212919