The complexity of biological membranes is the cause of artificial membrane models development as essential tools for understanding the mechanisms of interaction between drugs and cell membrane. This thesis focuses on the study of specific and non specific interactions between new glycoconjugated porphyrins used in photodynamic therapy (PDT) and retinoblastoma biomimetic membrane models (monolayers, supported planar bilayers and liposomes) expressing at their surface a mannose specific lectin. The main characterization techniques used in this study, are the Quartz Crystal Microbalance with Dissipation Monitoring (QCM-D) and Dynamic Light Scattering (DLS). Glycoconjugated porphyrins are proved as promising molecules which are able to interact in a non specific (passive penetration) and specific ways (Lectin-like receptors targeting) with retinoblastoma membrane models.
Analysis of intramembranal penetration mechanisms of glycoconjugated porphyrins used in photodynamic therapy of cancers : Modelization of specific and non specific interactions