Muscular metabolism regulation by SREBP-1 transcription factors : role of MRFs, SIRT-1 and ceramides
type: Dataset
description: SREBP-1 transcription factors are involved in lipid metabolism regulation. Recently, in vitro and in vivo studies have shown that SREBP-1a or SREBP-1c overexpression induce muscular atrophy and block muscular differentiation, notably by inhibiting structural proteins and Myogenics Regulatory Factors (MRFs) expression. The aims of this work are the mecanism determination of the muscular atrophy induced by SREBP-1 overexpression and the elucidation of the role of SIRT1 proteins on SREBP-1 regulation.The muscular atrophy results from an imbalance between the amount of synthesized and degraded proteins. In our studies, we shown that SREBP-1 regulates protein synthesis and protein degradation, respectively via a negative control of MRFs expression and via a control of atrogenes expression, MuRF1 and Atrogin-1. In skeletal muscle, we shown that SIRT1 desacetylase enzyme regulates SREBP-1 transcription activity. Because of SREBP-1 and SIRT1 proteins involvement in lipid metabolism regulation, our results suggest a new signalisation pathway linking energetic metabolism and SREBP-1 transcriptionnal activity in muscle. As SIRT1 and SREBP-1 have a role on lipid and muscular metabolism, we took an interest in phospholipids involvement and more specifically in ceramides involvement in muscle mass regulation. Our studies shown that the regulation of the amount of ceramids by the TNFα regulates muscle mass. Thus, our work allows to identify new links between lipid metabolism and muscle mass and metabolism regulation.
landing page: https://theses.hal.science/tel-00794521
identifier: NNT: 2012LYO10269
keyword: atrogin-1
keyword: atrophie-musculaire
keyword: infoeu-reposemanticsdoctoralthesis
keyword: mrfs
keyword: murf1
keyword: muscular-atrophy
keyword: protein-synthesis
keyword: sdvsalife-sciences-q-bioagricultural-sciences
keyword: sirt1
keyword: srebp-1
keyword: synthese-proteique
keyword: theses
issued: 2026-05-14T04:04:33.869120
modified: 2026-05-14T04:04:33.869125
language: fr
contact point: Organization
  fn: CCSD

test_moissonnage_selune
type: Agent

Muscular metabolism regulation by SREBP-1 transcription factors : role of MRFs, SIRT-1 and ceramides
type: Distribution
format: HTML
access URL: https://theses.hal.science/tel-00794521
issued: 2026-05-14T04:04:33.913089
modified: 2026-05-14T04:04:33.835939