Renal consequences of toxic and ischemic stress-induced unfolded protein response
type: Dataset
description: Native and grafted kidneys are stressed by multiple specific or non-specific insults leading to progressive structural deterioration. Responses to these insults are adaptive and preserve cell survival but may also promote inflammation, fibrosis and apoptosis. The most important of these adaptive pathways are HIF1α pathway, mTOR pathway, autophagy, unfolded protein response (UPR). The consequences of the UPR in kidney injuries are not well known. The objective of this study is to delineate the mechanisms and consequences of the activation of the UPR in response to toxic (cyclosporine) and ischemic (glucose starvation) stresses in two distinct cellular models (arterial endothelial cells and renal tubular cells). Here, we showed that UPR was engaged in cyclosporine-induced endothelial phenotypic changes, glucose starvation-induced inflammatory and angiogenic responses: NF-κB regulation by Ire1; distinct VEGF, bFGF and angiogenin regulation by Perk and Ire1. UPR is subtly modulated since its transducers do not induce identical processes. In conclusion these comprehensive works, we demonstrate the UPR is implicated in stress-induced adaptive pathways with different downstream responses according to the effector. Renal tissue degradation could be prevented by discovering and validating early biomarker and UPR modulators.
identifier: NNT: 2012PA05P626
issued: 2026-05-14T05:37:35.259090
language: fr
modified: 2026-05-14T05:37:35.259096
contact point: Organization
  fn: CCSD
keyword: angiogenese
keyword: angiogenesis
keyword: ciclosporine
keyword: cyclosporine
keyword: endoplasmic-reticulum-stress
keyword: inflammation
keyword: infoeu-reposemanticsdoctoralthesis
keyword: ischemia
keyword: ischemie
keyword: kidney
keyword: kidney-graft
keyword: rein
keyword: reponse-aux-proteines-mal-repliees
keyword: sdvmheplife-sciences-q-biohuman-health-and-pathology
keyword: stress-du-reticulum-endoplasmique
keyword: theses
keyword: transplantation-renale
keyword: unfolded-protein-response
landing page: https://theses.hal.science/tel-00793364

Renal consequences of toxic and ischemic stress-induced unfolded protein response
type: Distribution
format: HTML
issued: 2026-05-14T05:37:35.264693
modified: 2026-05-14T05:37:35.220932
access URL: https://theses.hal.science/tel-00793364

test_moissonnage_selune
type: Agent