Synthesis of new pyrazolo[1,5-a]pyrimidinic derivatives aiming at biological activity
type: Distribution
access URL: https://theses.hal.science/tel-00789954
format: HTML
issued: 2026-05-14T09:46:24.859432
modified: 2026-05-14T09:46:24.761042

Synthesis of new pyrazolo[1,5-a]pyrimidinic derivatives aiming at biological activity
type: Dataset
contact point: Organization
  fn: CCSD
keyword: palladium-catalyzed-reactions
keyword: reactions-pallado-catalysees
keyword: intramolecular-arylation
keyword: pyrazolo15-apyrimidine
keyword: micro-onde
keyword: direct-heteroarylation
keyword: condensation
keyword: microwave
keyword: one-pot
keyword: heteroarylation-directe
keyword: theses
keyword: chimothechemical-sciencesother
keyword: infoeu-reposemanticsdoctoralthesis
keyword: arylation-intramoleculaire
keyword: pyran-2-one
landing page: https://theses.hal.science/tel-00789954
description: Our thesis works concern the development of new methods of synthesis allowing a rapid and effective access to variously functionalized pyrazolo [1,5-a] pyrimidines derivatives.First, we were explored the study and the application of the condensation of the pyran-2 one with 5(3)-amino-3 (5)-arylpyrazoles whether it is by classic heating or under microwaves. Indeed, we have described the first example of the direct and regioselective palladium-catalyzed (hetero)arylation of 5,7-dimethylpyrazolo[1,5-a]pyrimidine, the reaction may be inducted to occur at either an sp2 or an sp3 carbon atom.The last part of this report was dedicated to the preparation of some 7-substituted pyrazolo[1,5-a]pyrimidines via a one-pot two steps palladium-catalyzed direct CH-arylation followed by a saponification-decarboxylation.
identifier: NNT: 2012ORLE2025
issued: 2026-05-14T09:46:24.792266
language: fr
modified: 2026-05-14T09:46:24.792272

test_moissonnage_selune
type: Agent