@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00787736v1> a dcat:Dataset ;
    dct:description """
              B7-H1 (PD-L1) is a B7-related protein that inhibits T-cell responses. B7-H1 participates in the immunoescape of cancer cells and is also involved in the long-term persistence of leukemic cells in a mouse model. B7-H1 can be constitutively expressed by cancer cells but is also induced by various stimuli. We therefore examined the constitutive and inducible expression of B7-H1 and the consequences of expression in human acute myeloid leukemia (AML). We analyzed B7-H1 expression in a cohort of 79 patients with AML. Blast cells were also studied after incubation with interferon-gamma or TLR ligands. Functionality was evaluated by cytotoxic T-cell activity against blast cells. Expression of B7-H1 at diagnosis was high in 18% of patients. Expression of toll-like receptors (TLR) 2, 4, and 9 was detected in one-third of AML samples. Expression of TLR2 and TLR4 ligands or IFN-&#61543; induced by B7-H1 was found to protect AML cells from CTL-mediated lysis. Spontaneous B7-H1 expression was also found to be enhanced at relapse in some patients. MEK inhibitors including UO126 and AZD6244 reduced B7-H1 expression and restored CTL-mediated lysis of blast cells. In AML, B7-H1 expression by blasts represents a possible immune escape mechanism. The inducibility of B7-H1 expression by IFN-&#61543; or TLR ligands suggests that various stimuli, either produced during the immune response against leukemia cells or released by infectious microorganisms, could protect leukemic cells from T-cells. The efficacy of MEK inhibitors against B7-H1-mediated inhibition of CTLs suggests a possible cancer immunotherapy strategy using targeted drugs.
            """ ;
    dct:identifier "NNT: 2012LIL2S016" ;
    dct:issued "2026-05-14T12:51:33.719428"^^xsd:dateTime ;
    dct:language "fr" ;
    dct:modified "2026-05-14T12:51:33.719434"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Immuno editing in myeloid pathology" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00787736v1/resource/a91bc6d5-3701-40d7-9924-e7a7a88785dc> ;
    dcat:keyword "acute-myeloid-leukemia",
        "aml",
        "b7-h1-pd-l1",
        "cd274",
        "immuno-evasion",
        "infoeu-reposemanticsdoctoralthesis",
        "leucemies-aigues-myeloblastique",
        "sdvmheplife-sciences-q-biohuman-health-and-pathology",
        "theses" ;
    dcat:landingPage <https://theses.hal.science/tel-00787736> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00787736v1/resource/a91bc6d5-3701-40d7-9924-e7a7a88785dc> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-14T12:51:33.725766"^^xsd:dateTime ;
    dct:modified "2026-05-14T12:51:33.686094"^^xsd:dateTime ;
    dct:title "Immuno editing in myeloid pathology" ;
    dcat:accessURL <https://theses.hal.science/tel-00787736> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .

<https://theses.hal.science/tel-00787736> a foaf:Document .