Modeling and analysis of all the positron emitters simulation steps generated during the treatment phase in protontherapy - from the beam to the PET camera - for the follow-up of the irradiations
type: Dataset
description: The protontherapy is an innovative technique for cancer treatment in critical areas, such as the eye or the head. Even though the interaction of protons with human tissues is a well-known physical phenomenon which gives rise to the protontherapy, there are uncertainties on the proton trajectory due to heterogeneities in the irradiated tissue, the calculation of the beam parameters in the planning treatment affects the theoretical benefits of the protons and the chosen dose delivery process. Thus, methods for irradiation quality control have been suggested. Most of them rely on utilizing the mapping of the positron emitters generated during the irradiation. They are detectable and quantifiable thanks to the use of the PET (positron emitter tomography), a medical imaging technique mainly used for the cancer expansion assessment. PET acquisitions were proposed and then realized on phantoms and patients after protontherapy. The quality control relies on comparing the measured radioactive distribution to the simulated β+ distribution. The modeling of the positronic activity generated by protons in the irradiated area can be divided into three steps: the simulation of the proton beam, the modeling of the proton interactions in the irradiated object and the modeling of the PET acquisition. Different ways of simulating these steps are possible. This PhD work suggests different ways of modeling the three steps and evaluates theirs benefits for the irradiation quality control. We have restrained our evaluation to the verification of the proton range and to the uncertainties related to the proton range. This research work utilizes on irradiations in homogenous and inhomogeneous areas in a head model. We have compared the uncertainties on the proton range measured thanks to the following β+ distributions: 1) A β+ distribution obtained by modeling the irradiation with a proton beam simulated analytically and simulated using the complete Monte Carlo method; 2) A Monte Carlo model…
landing page: https://theses.hal.science/tel-00778996
identifier: NNT: 2012PA112422
keyword: controle-de-lirradiation
keyword: cross-sections
keyword: emetteur-de-positons
keyword: infoeu-reposemanticsdoctoralthesis
keyword: irradiation-monitoring
keyword: modelisation
keyword: modelling
keyword: monte-carlo-simulation
keyword: pet
keyword: physcondcm-genphysics-physicscondensed-matter-cond-matother-cond-matother
keyword: positron-emitters
keyword: protontherapie
keyword: protontherapy
keyword: radiotherapie
keyword: radiotherapy
keyword: sections-efficaces
keyword: simulation-monte-carlo
keyword: tep
keyword: theses
issued: 2026-05-15T01:08:44.175625
modified: 2026-05-15T01:08:44.175632
language: fr
contact point: Organization
  fn: CCSD

test_moissonnage_selune
type: Agent

Modeling and analysis of all the positron emitters simulation steps generated during the treatment phase in protontherapy - from the beam to the PET camera - for the follow-up of the irradiations
type: Distribution
format: HTML
access URL: https://theses.hal.science/tel-00778996
issued: 2026-05-15T01:08:44.234970
modified: 2026-05-15T01:08:44.129019