Applications of derivatives of pharmacological modulation of reactive oxygen species form for optimization of patients treated with chemotherapy
type: Dataset
contact point: Organization
  fn: CCSD
keyword: oxydative-stress
keyword: sdvmheplife-sciences-q-biohuman-health-and-pathology
keyword: aopp
keyword: stress-oxydant
keyword: hepatocellular-carcinoma
keyword: sorafenib
keyword: ros
keyword: chimiotherapie
keyword: theses
keyword: carcinome-hepatocellulaire
keyword: infoeu-reposemanticsdoctoralthesis
keyword: chemotherapy
keyword: tyrosin-kinase-inhibitors
keyword: inhibiteurs-de-tyrosine-kinase
landing page: https://theses.hal.science/tel-00776282
description: Reactive oxygen species (ROS) forms have an established role in oncogenesis and tumor cell function by increasing the capacity of proliferation and cell invasion. ROS have a lower toxicity in normal cells where the level of oxidative stress is low and redox systems operational. Pharmacological modulation of redox balance enhances the effectiveness of cytotoxic molecules that act on the FRO. The anti-tumor activity of chemotherapy is mediated in part by oxidative stress, we initially interested in the changes of oxidative stress during treatment with sorafenib (Nexavar©), an inhibitor of tyrosine kinases. We have demonstrated anti-tumor activity of sorafenib due to increased production of superoxide anion by cells. This allowed us to identify a predictive marker of efficacy of sorafenib dosing Products Advanced Oxidation Protein (AOPP) in the serum of patients with cirrhosis develop hepatocellular carcinoma. Knowing that the antitumor efficacy of conventional chemotherapy is partly through the induction of ROS, we are interested in a second time mangafodipir, a modulator of oxidative stress, which is known to increase the therapeutic index of cytotoxic agents in vivo. Mangafodipir reduces the toxic effects of oxidative stress in non-tumor cells and potentiates the anti-tumor activity of oxaliplatin. These data led us to explore in vivo and in vitro the mechanism of neurotoxicity induced by oxaliplatin and the protective role of mangafodipir. We observed in a mouse model that mangafodipir prevents neurotoxicity induced by oxaliplatin in the myelin sheath. We confirmed these results in humans in a phase II study. Given the higher levels of ROS in tumor cells compared to normal cells, several strategies have been proposed to selectively target tumors without damaging healthy tissue with modulators of oxidative stress. Our third area of work has aimed to identify and validate novel molecules related to the modulation of ROS. This study was conducted as part of a project …
identifier: NNT: 2012PA05T038
issued: 2026-05-15T07:00:45.513638
language: fr
modified: 2026-05-15T07:00:45.513643

Applications of derivatives of pharmacological modulation of reactive oxygen species form for optimization of patients treated with chemotherapy
type: Distribution
access URL: https://theses.hal.science/tel-00776282
format: HTML
issued: 2026-05-15T07:00:45.519896
modified: 2026-05-15T07:00:45.478311

test_moissonnage_selune
type: Agent