Regulation of the NADPH oxidase NOX1 : a crucial role of NOXA1 (NOX Activator 1) and NOXO1 (NOX Organizer 1) phosphorylation
type: Dataset
description: The NOX family of NADPH oxidases are enzymes which function is dedicated to the production of reactive oxygen species. NOX1, a member of this family is expressed abundantly in the intestine and its disregulation could be linked to inflammatory diseases such as inflammatory bowel diseases. However, the molecular basis of NOX1 regulation remains unclear. During my thesis, I demonstrated that 1) NOXA1, the activator cytosolic subunit of the NOX1 complex, is phosphorylated and its phosphorylation prevents hyperactivation of NOX1 in order to maintain a constitutive activity which would not be too excessive. 2) phosphorylation of human NOXO1, the organizer subunit of the complex is a prerequisite of full activation of NOX1. Taken together, these results demonstrate that NOX1 is tightly regulated by phosphorylation events. By this mean, NOX1 could be involved in host immune defense of the intestine.
identifier: NNT: 2011PA11T103
issued: 2026-05-15T14:13:22.885636
language: fr
modified: 2026-05-15T14:13:22.885643
contact point: Organization
  fn: CCSD
keyword: fro
keyword: inflammation
keyword: infoeu-reposemanticsdoctoralthesis
keyword: nox1
keyword: noxa1
keyword: noxo1
keyword: phosphorylation
keyword: reactive-oxygen-species
keyword: regulation
keyword: regulation-mechanism
keyword: sdvsalife-sciences-q-bioagricultural-sciences
keyword: theses
landing page: https://theses.hal.science/tel-00769943

Regulation of the NADPH oxidase NOX1 : a crucial role of NOXA1 (NOX Activator 1) and NOXO1 (NOX Organizer 1) phosphorylation
type: Distribution
format: HTML
issued: 2026-05-15T14:13:22.930193
modified: 2026-05-15T14:13:22.858613
access URL: https://theses.hal.science/tel-00769943

test_moissonnage_selune
type: Agent