H ypothalamic control of the energetic homeostasis : Impact of the maternal environment and the implication of the CNTF
type: Dataset
description: Obesity is a major health disease which involves numerous metabolic disorders. Increasing evidence suggests that the risk of developing the pathology in adulthood may be influenced through inappropriate perinatal nutrition. In our study, we first investigated the impact of a maternal high-fat (HF) diet, which is known to induce hypothalamic leptin resistance in adult offspring (Férézou-Viala et al., 2007), to develop obesity in a rich diet environment (P diet). Our results showed that surprisingly, HF maternal diet protected offspring against body weight gain induced by P diet. In a second part of the thesis, we studied mechanisms of action of CNTF, a neurocytokine which could protect some people against body weight gain induced by a P diet (Vacher et al., 2008). Results of this study showed that CNTF ant its subunits receptors could translocate to the hypothalamic cell nucleus to induced POMC transcription.
identifier: NNT: 2011PA11T112
issued: 2026-05-15T14:11:09.262823
language: fr
modified: 2026-05-15T14:11:09.262828
contact point: Organization
  fn: CCSD
keyword: astrocytes
keyword: cntf
keyword: energetic-homeostasis
keyword: homeostasie-energetique
keyword: hypothalamus
keyword: immunohistochimie
keyword: infoeu-reposemanticsdoctoralthesis
keyword: leptin-resistance
keyword: leptino-resistance
keyword: maternal-high-fat-diet
keyword: microcopie-confocale
keyword: microscopie-electronique-a-transmission
keyword: noyau
keyword: noyau-arque
keyword: nucleus
keyword: palatable-diet
keyword: regime-maternel-hf
keyword: run-on
keyword: sdvsalife-sciences-q-bioagricultural-sciences
keyword: theses
landing page: https://theses.hal.science/tel-00769940

H ypothalamic control of the energetic homeostasis : Impact of the maternal environment and the implication of the CNTF
type: Distribution
format: HTML
issued: 2026-05-15T14:11:09.267505
modified: 2026-05-15T14:11:09.202966
access URL: https://theses.hal.science/tel-00769940

test_moissonnage_selune
type: Agent