Identification of drug-specific T lymphocytes in non-allergic donors
type: Dataset
description: In allergic patients, antibodies like IgE or T-lymphocytes specific for the drugimplicated can be detected and measured. Presence of T-lymphocytes specific for the drugin allergic patients suggested the presentation of the culprit drug to T-lymphocytes byantigen presenting cells like dendritic cells.We were interested in better understanding the implication of T-lymphocytes anddendritic cells in the development of antibiotics allergies such as penicillin G (or Benzyl-Penicillin) or sulfamethoxazole.The results obtained in this work allowed us: i) to demonstrate the presence ofbenzyl-penicillin-specific T cells in the peripheral blood of non-allergic donors, at adetectable frequency; ii) to develop two approaches: one experimental and one usingmodelisation for the identification of epitopes potentially presented to T-lymphocytes andiii) to study the effect of drugs on DC.The perspectives of this research work are to better understand the mechanismsimplicated in drug allergies and to develop predictive tests for “drug allergic potential", inorder to be able to better predict drug allergies during drug development.
landing page: https://theses.hal.science/tel-00769921
identifier: NNT: 2012PA114834
keyword: allergie
keyword: allergy
keyword: antibiotics
keyword: antibiotiques
keyword: bio-conjugates
keyword: bio-conjugues
keyword: cellules-dendritiques
keyword: dendritics-cells
keyword: hapten
keyword: haptene
keyword: infoeu-reposemanticsdoctoralthesis
keyword: lymphocytes-t
keyword: penicillin-g
keyword: penicilline-g
keyword: sdvsalife-sciences-q-bioagricultural-sciences
keyword: sulfamethoxazole
keyword: t-lymphocytes
keyword: theses
issued: 2026-05-28T21:39:57.570708
modified: 2026-05-28T21:39:57.570713
language: fr
contact point: Organization
  fn: CCSD

test_moissonnage_selune
type: Agent

Identification of drug-specific T lymphocytes in non-allergic donors
type: Distribution
format: HTML
access URL: https://theses.hal.science/tel-00769921
issued: 2026-05-28T21:39:57.688268
modified: 2026-05-28T21:39:57.517105