Tribological operation of pathological synovial joints: Role of phospholipidic interfaces
type: Dataset
description: In order to improve the effectiveness of joint diseases' treatments, given their complexity and magnitude, recent studies have highlighted the role of lipid assemblies associated with the discontinuous structure of the synovial fluid (SF) in the tribological performance of joint operation. Thus, an ex vivo tribological model (AM Sfarghiu, PhD thesis, 2006) providing a "basic pattern" for joint biolubrification was developed. It consists of the stack of phospholipidic interfaces and aqueous layers. Using this model, the objective of this work was to study the evolution of phospholipidic interfaces of SF within pathological state. Therefore, a nano-bio-tribological methodology combining biochemical, physicochemical, nano-mechanical and tribological analysis was used. The results of these analyses show: the influence of even small rubbing surfaces' roughness characteristics of early stage illness and that of phospholipidic interfaces' properties (related to their composition change) on the mechanical strength, changes in friction and in situ degradation of lipidic assemblies of pathological SF. The tribological operation is highlighted by enzymes' associated with diseases. Thus, joint operation depends on the mechanical strength of phospholipidic interfaces and to obtain very low friction coefficients, velocity accommodation must be done at the level of hydration layers surrounding ions in the aqueous solution. These results would therefore allow better understanding of the evolution of phospholipidic interfaces in joint diseases and of the proper cause/consequence sequence responsible for a joint disease in order to develop more effective, targeted and non prosthetic treatments.
landing page: https://theses.hal.science/tel-00766779
keyword: analyse-lipidomique
keyword: articulation-synoviale-pathologique
keyword: assemblages-lipidiques
keyword: atomic-force-microscopy
keyword: biotribological-triplet
keyword: coefficient-de-frottement
keyword: ex-vivo-model
keyword: fluide-synovial
keyword: fluorescence-optical-microscopy
keyword: friction
keyword: hydration-lubrication-layers
keyword: infoeu-reposemanticsdoctoralthesis
keyword: lipid-assemblies
keyword: lipidomics
keyword: lubrification-par-couches-dhydratation
keyword: microscopie-de-force-atomique
keyword: microscopie-optique-en-fluorescence
keyword: modele-ex-vivo
keyword: nano-bio-tribologie
keyword: nanobiotribology
keyword: pathological-synovial-joint
keyword: phospholipides
keyword: phospholipids
keyword: physcondcm-genphysics-physicscondensed-matter-cond-matother-cond-matother
keyword: physmecabiomphysics-physicsmechanics-physicsbiomechanics-physicsmed-ph
keyword: sdvbbmbclife-sciences-q-biobiochemistry-molecular-biologybiochemistry-q-biobm
keyword: spimecabiomengineering-sciences-physicsmechanics-physicsmed-phbiomechanics-physicsmed-p
keyword: synovial-fluid
keyword: theses
keyword: triplet-bio-tribologique
issued: 2026-05-30T09:19:50.735047
modified: 2026-05-30T09:19:50.735055
language: fr
contact point: Organization
  fn: CCSD

test_moissonnage_selune
type: Agent

Tribological operation of pathological synovial joints: Role of phospholipidic interfaces
type: Distribution
format: HTML
access URL: https://theses.hal.science/tel-00766779
issued: 2026-05-30T09:19:50.807927
modified: 2026-05-30T09:19:50.652404