Resorbable microspheres for embolisation and chemo-embolisation
type: Dataset
description: Therapeutic embolization is nowadays a first line treatment for haemorrhage, arteriovenous malformation or tumors. Among different embolization agents, non degradable microspheres(Embozene®, Bead BlockTM,…) are the most employed thanks to their well calibrated spherical shape which allows good occlusion. In some cases including treatment of uterine fibroids or chemo-sensitive tumors, it may be interesting to achieve a temporary embolization to avoid definitive destruction of the tissue. Temporary embolization would be possible using biodegradable microspheres. The aim of our work was to develop degradable microspheres having all requiredcharacteristics to be used as embolization material (well calibrated in size, biocompatible, rigide enough to resist blood pressure but elastic enough to remain intact during injection through catheter). To this purpose, we have developed hydrolysable hydrogel based microspheres by suspension polymerization. A wide range of microspheres was synthesized by varying the type of crosslinker and composition of the polymerization medium. In vitro test showed that the microspheres have suitable characteristics to pass through catheter. Degradation studies revealed a rapid diminution of G’ modulus and the pH of the supernatants, accompanied by an increase of swelling ratio due to the hydrolysis of the crosslinkings. Although microspheres were not totally degradable as expected (since a side reaction had created non degradable crosslinking during the polymerisation), characterisations showed promising results that the degradation did occur within a suitable time scale requirements for temporal embolization.
identifier: NNT: 2012PA114808
issued: 2026-05-31T22:27:46.103404
language: fr
modified: 2026-05-31T22:27:46.103409
contact point: Organization
  fn: CCSD
keyword: chimothechemical-sciencesother
keyword: crosslink
keyword: degradable
keyword: degradation
keyword: elasticite
keyword: elasticity
keyword: embolisation
keyword: hydrogel
keyword: infoeu-reposemanticsdoctoralthesis
keyword: microsphere
keyword: plga
keyword: polymerisation-en-suspension
keyword: reticulation
keyword: sdvmheplife-sciences-q-biohuman-health-and-pathology
keyword: suspension-polymerization
keyword: theses
landing page: https://theses.hal.science/tel-00763493

Resorbable microspheres for embolisation and chemo-embolisation
type: Distribution
format: HTML
issued: 2026-05-31T22:27:46.127463
modified: 2026-05-31T22:27:45.980444
access URL: https://theses.hal.science/tel-00763493

test_moissonnage_selune
type: Agent