The relative contribution of bone microarchitecture and its heterogeneity to mechanical behavior of human L3 vertebrae : an ex-vivo study
type: Dataset
description: Osteoporosis is characterized by altered bone quality and compromised bone strength leading to increased fracture risk. Measurement of areal bone mineral density (BMD) using dual-energy X-ray absorptiometry (DXA) is the most widely used index of bone strength. However, BMD alone can only account for 40 to 70% of the variation of bone strength. This study aimed to determine: 1/ the respective role of cortical and trabecular microarchitecture to vertebral mechanical behavior, 2/ the role of trabecular microarchitecture heterogeneity and 3/ the mechanical behavior of a vertebra after simulated mild fracture and its determinants. Our data imply that measurements of cortical thickness and curvature as well as determination of trabecular microarchitecture heterogeneity enhance prediction of vertebral fragility. We found marked variation in the post-fracture load-bearing capacity following simulated mild vertebral fractures. Bone microarchitecture, but not bone mass, was associated with post-fracture mechanical behavior of vertebrae.
identifier: NNT: 2010LYO10144
issued: 2026-05-16T06:43:15.994561
language: fr
modified: 2026-05-16T06:43:15.994602
contact point: Organization
  fn: CCSD
keyword: -ct
keyword: biomecanique
keyword: biomechanics
keyword: bone-mass
keyword: fracture-vertebrale
keyword: hr-pqct
keyword: infoeu-reposemanticsdoctoralthesis
keyword: masse-osseuse
keyword: microarchitecture
keyword: osteoporose
keyword: osteoporosis
keyword: sdvmheplife-sciences-q-biohuman-health-and-pathology
keyword: theses
keyword: vertebral-fracture
landing page: https://theses.hal.science/tel-00703704

The relative contribution of bone microarchitecture and its heterogeneity to mechanical behavior of human L3 vertebrae : an ex-vivo study
type: Distribution
format: HTML
issued: 2026-05-16T06:43:16.032841
modified: 2026-05-16T06:43:15.955568
access URL: https://theses.hal.science/tel-00703704

test_moissonnage_selune
type: Agent