Modifications of lipidic nanocapsules by post-formulation processes. Creation of multifunctional nanoparticles evaluated as drug vectors.
type: Dataset
description: This work established the identity card of nanoparticles developped in our laboratory; these nanoparticles are called lipidic nanocapsules. Indeed, these lipidic nanocapsules were characterized by dynamic light scattering and also by small angle neutron scattering. These experiments have demonstrated the structure of the lipidic nanocapsules as core-shell systems: an oily core surrounded by a mix monolayer of surfactants. By the way, starting from these core-shell systems, we have developped two methodologies able to produce multifunctional lipidic nanocapusles. The first one is the post-insertion process, initialy developped onto liposomes; the second one is a new process based on a transacylation reaction between the surfactants of lipidic nanocapsules and an another molecule presenting a high interest towards pharmaceuticals sciences.We have demonstrated that these new nanocapsules had new properties such the ability to deliver small interfering RNA (siRNA) into mammalian cells.
issued: 2026-05-21T09:13:29.032337
language: fr
modified: 2026-05-21T09:13:29.032344
contact point: Organization
  fn: CCSD
keyword: infoeu-reposemanticsdoctoralthesis
keyword: modifications-post-formulation
keyword: nanocapsules
keyword: nanoparticles
keyword: nanoparticules
keyword: post-formulation-modifications
keyword: sdvneulife-sciences-q-bioneurons-and-cognition-q-bionc
keyword: sirna
keyword: theses
landing page: https://theses.hal.science/tel-00689362

Modifications of lipidic nanocapsules by post-formulation processes. Creation of multifunctional nanoparticles evaluated as drug vectors.
type: Distribution
format: HTML
issued: 2026-05-21T09:13:29.114083
modified: 2026-05-21T09:13:28.998089
access URL: https://theses.hal.science/tel-00689362

test_moissonnage_selune
type: Agent