@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00687029v1> a dcat:Dataset ;
    dct:description """
              Andrographis paniculata is an Asian Echinacea. This plant is widely used in traditionnal remedies and folkloric medicines for thousands years and is reported to possess a wide spectrum of biological activities. A large number of diterpenoid ent-labdanes have been isolated from this plant, where the major compound is andrographolide, a diterpenoid lactone, that exhibits interesting anti-inflammatory activities on the NFB way. In order to understand and improve the anti-inflammatory activity of these compounds, we implemented a program aimed at their study. Qualitative analysis of crude extracts from dietary supplements allowed to obtain three major natural compounds, which were in a second time chemically modified. These products, as well as the crude extracts, where the composition was determined by a quantitative method, were used for the study of anti-inflammatory activity. Our aim was also to modify andrographolide on some positions not accessible by hemisynthesis. So total and enantioselective synthesis of andrographolide was investigated. Two ways were studied: biomimetic pathway, and modification of a bicyclic precursor that already possessed the ent-labdane configuration (Wieland-Miescher ketone). Methodology using Wieland-Miescher ketone was divided in three parts (enantioselective cyclisation, cycle A functionalisation, cycle B functionalisation). By this way, the bicyclic core was successfully functionnalised and analogues of andrographolide were prepared.
            """ ;
    dct:identifier "NNT: 2011ORLE2046" ;
    dct:issued "2026-05-22T04:11:07.733003"^^xsd:dateTime ;
    dct:language "fr" ;
    dct:modified "2026-05-22T04:11:07.733008"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Study about an anti-inflammatory natural diterpenes family" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00687029v1/resource/bfa5f3eb-37d4-4551-8d05-4f8ab92af641> ;
    dcat:keyword "andrographolide",
        "cetone-de-wieland-miescher",
        "chimothechemical-sciencesother",
        "infoeu-reposemanticsdoctoralthesis",
        "theses",
        "wieland-miescher-ketone" ;
    dcat:landingPage <https://theses.hal.science/tel-00687029> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00687029v1/resource/bfa5f3eb-37d4-4551-8d05-4f8ab92af641> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-22T04:11:07.737030"^^xsd:dateTime ;
    dct:modified "2026-05-22T04:11:07.712534"^^xsd:dateTime ;
    dct:title "Study about an anti-inflammatory natural diterpenes family" ;
    dcat:accessURL <https://theses.hal.science/tel-00687029> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .

<https://theses.hal.science/tel-00687029> a foaf:Document .