@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00686770v1> a dcat:Dataset ;
    dct:description """
              The work reported in this thesis focuses on biomolecules immobilization for the development of multiparametric analysis tools on a biochip coupled with a colorimetric detection, applied to the characterization of biological samples and to diagnosis.The first concern was the development of high-throughput automated hybridization tests and immunotests on a filtration plate. This method led to the elaboration of an automated platform for extended blood group genotyping in collaboration with the Etablissement Français du Sang Rhône-Alpes (EFS-RA). It enables to analyze 96 samples in four hours and to characterize six genotypes per sample. Its analytical performances were validated on a panel of 293 blood donors.The second part of this work aimed to elaborate a new strategy for oligonucleotide immobilization on an innovative polymer (PolyshrinkTM) for the development of miniaturized analysis systems. Several approaches were evaluated and led to an in-situ immobilization of oligonucleotides in hydrogel dots technique. This method leads to 6 µm hydrogel dots with a diameter of 60 µm. Moreover it was demonstrated that such immobilized oligonucleotides were able to detect targets specifically and quantitatively using either a chemiluminescent or a colorimetric detection.
            """ ;
    dct:identifier "NNT: 2011LYO10196" ;
    dct:issued "2026-05-22T05:52:02.417339"^^xsd:dateTime ;
    dct:language "fr" ;
    dct:modified "2026-05-22T05:52:02.417350"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Biomolecule immobilisation for multiparametric analysis on biochips : application to high-throughput blood group genotyping" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00686770v1/resource/1f3b6c33-b927-4adf-83a5-9dfdcd37a1be> ;
    dcat:keyword "allergie",
        "allergy",
        "biochip",
        "biopuce",
        "blood-group-genotyping",
        "chimothechemical-sciencesother",
        "colorimetrie",
        "colorimetry",
        "diagnosis",
        "diagnostic",
        "dna-chip",
        "genotypage-erythrocytaire",
        "haut-debit",
        "high-throughput",
        "hydrogel",
        "infoeu-reposemanticsdoctoralthesis",
        "membrane",
        "polymorphisme-dun-nucleotide",
        "polyshrinktm",
        "protein-chip",
        "puce-a-adn",
        "puce-a-proteines",
        "single-nucleotide-polymorphism",
        "theses" ;
    dcat:landingPage <https://theses.hal.science/tel-00686770> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00686770v1/resource/1f3b6c33-b927-4adf-83a5-9dfdcd37a1be> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-22T05:52:02.435700"^^xsd:dateTime ;
    dct:modified "2026-05-22T05:52:02.344078"^^xsd:dateTime ;
    dct:title "Biomolecule immobilisation for multiparametric analysis on biochips : application to high-throughput blood group genotyping" ;
    dcat:accessURL <https://theses.hal.science/tel-00686770> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
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<https://theses.hal.science/tel-00686770> a foaf:Document .