Role of aldose reductases in the physiology of white adipose tissue : murine genetic models of loss and gain of function
type: Dataset
description: White adipose tissue development is tightly regulated by pro-and anti-adipogenic factors. In obesity, its increased development leads to many metabolic complications. To date, little is known about the factors that control negatively its growth. In this context, the laboratory has focused researches on the murine aldose reductase Akr1b7 role in white adipose tissue. Akr1b7 is expressed in stromal vascular fraction of white adipose tissue and exhibits an anti-adipogenic action on a preadipocyte cell line. Generation and study of Akr1b7-/- knockout mice allows us to demonstrate that lack of Akr1b7 leads to adipose tissue expansion due to hypertrophy and hyperplasia of adipose cells associated to insulin resistance. Akr1b7-/- mice are not hyperphagic but show reduced basal metabolic rate. This phenotype confirms Akr1b7 involvement in adipose tissue physiology. Akr1b7 regulates development of adipose tissue by a PGF2α-dependent inhibition of both adipogenesis and lipogenesis. On the other hand, we have developed a transgenic murine model over-expressing the human aldose reductase AKR1B1 in adipose tissue. Against all odds and contrary to Akr1b7, this model shows a pro-adipogenic effect of AKR1B1. These in vivo data reveal new and opposed activities of different aldose reductase isoforms and open new avenues to understand the mecanisms regulating fat homeostasis and its disturbances.
landing page: https://theses.hal.science/tel-00686589
identifier: NNT: 2011CLF22178
keyword: adipogenese
keyword: adipogenesis
keyword: adipose-tissue
keyword: aldose-reductase
keyword: aldose-reductases
keyword: infoeu-reposemanticsdoctoralthesis
keyword: lipogenese
keyword: lipogenesis
keyword: pgf2
keyword: sdvmheplife-sciences-q-biohuman-health-and-pathology
keyword: theses
keyword: tissu-adipeux
issued: 2026-05-22T06:43:28.903126
modified: 2026-05-22T06:43:28.903134
language: fr
contact point: Organization
  fn: CCSD

test_moissonnage_selune
type: Agent

Role of aldose reductases in the physiology of white adipose tissue : murine genetic models of loss and gain of function
type: Distribution
format: HTML
access URL: https://theses.hal.science/tel-00686589
issued: 2026-05-22T06:43:28.961676
modified: 2026-05-22T06:43:28.863409