Study of the maurocalcine as a cell penetrating peptide
type: Dataset
description: Maurocalcine (MCa) is a 33 mer toxin initially identified from a tunisian scorpion venom, scorpio maurus palmatus. This peptide initially triggered our interest for its pharmacological activity on Ryanodine Receptor type 1 (RyR1) of skeletal muscles. In studying how this toxin reaches the intracellular RyR1, it has been shown that MCa could be placed in the growing family of cell penetrating peptides. Since the discovery that MCa can act as a transport agent for the intracellular delivery of fluorescent streptavidine, data have accumulated to illustrate the amazing biotechnological properties of this toxin. Several new analogs have been produced that keep cell penetration properties and lose pharmacological activity of the native molecule. This is the case for a linear analog of MCa synthesized by replacing internal cysteine residues by aminobutyric acid, or by the synthesis of a MCa analog with all its amino acid in D conformation. MCa proved efficient for the intracellular delivery of nanoparticles leading to a myriad of hi-tech applications. Finally, MCa has been grafted on an anti-tumor agent, doxorubicin, to made chemo-resistant tumor cells chemo-sensitive. So it seems that MCa begins its career as a biotechnological tool, and that this toxin will be helpful to see the light on the mechanistic aspects of RyR function.
identifier: NNT: 2011GRENV028
issued: 2026-05-22T18:24:33.059493
language: fr
modified: 2026-05-22T18:24:33.059501
contact point: Organization
  fn: CCSD
keyword: cell-imaging
keyword: cell-penetrating-peptide
keyword: delivrement-de-molecules-actives
keyword: drug-delivery
keyword: imagerie
keyword: infoeu-reposemanticsdoctoralthesis
keyword: peptide-de-penetration-cellulaire
keyword: sdvotlife-sciences-q-bioother-q-bioot
keyword: theses
landing page: https://theses.hal.science/tel-00685113

Study of the maurocalcine as a cell penetrating peptide
type: Distribution
format: HTML
issued: 2026-05-22T18:24:33.139509
modified: 2026-05-22T18:24:33.024109
access URL: https://theses.hal.science/tel-00685113

test_moissonnage_selune
type: Agent