@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00648421v2> a dcat:Dataset ;
    dct:description """
              Innate immune response which is characterized by antiviral cytokines such as interferon-alpha (IFN-, is essential during viral infections. Plasmacytoid dendritic cells (pDC) are the main IFN- producer cells. We demonstrated that HTLV-1 free viruses induced a strong IFN- production by pDC. Unstimulated pDC were in fact dormant cells stocking intracellular proapoptotic ligand TRAIL (TNF-Related Apoptosis Inducing Ligand), which was quickly mobilized at the cell surface of pDC after Toll-like receptor 7 activation. Then, pDC acquire a new killer phenotype, the IKpDC (Interferon producing killer pDC). This is the first demonstration that HTLV-1 free viruses can induce an innate immune response by pDC.Plasma levels of IFN- have been found in HIV-1-infected patients, suggesting a role of IFN- in HIV-associated disease. We hypothesized in our HIV in vitro model the implication of TRAIL/DR5 pathway in CD4 T cells massive depletion observed in HIV-1-infected patients.A population of HIV-infected patients, called « HIV Controllers » (HIC), do not progress to AIDS despite HIV infection, control their viral load and their CD4 T cells depletion. We have then study IFN/TRAIL/DR5 pathway of these patients. Our proteomic and genomic analysis revealed a default of DR5 expression at the cell surface of CD4 T cells from HIV controllers in contrast to progressor patients. DNA sequencing revealed a homozygous substitution in the exon 1 of DR5 gene from HIC. The consequence of this substitution is the change of one amino-acid in the leader region of DR5 protein. Thus, DR5 is uncleaved and is sequestrated in the intracellular copartements in CD4 T cells. The lack of DR5 cell surface expression in HIV Controllers may explain the maintain of CD4+ T cells count and thus the non progression to AIDS.
            """ ;
    dct:identifier "NNT: 2011PA11T087" ;
    dct:issued "2026-05-30T12:40:41.940484"^^xsd:dateTime ;
    dct:language "fr" ;
    dct:modified "2026-05-30T12:40:41.940496"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Innate Immune Response of plasmacytoid dendritic cells during retroviral stimulation (HTLV-1, HIV-1)" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00648421v2/resource/7cb1c69c-dcf5-4795-9e68-ede501966c21> ;
    dcat:keyword "apoptose",
        "apoptosis",
        "cellules-dendritiques-plasmacytoides",
        "hiv-controllers-patients",
        "infoeu-reposemanticsdoctoralthesis",
        "interferon-",
        "patients-hiv-controllers",
        "plasmacytoid-dendritic-cells",
        "sdvmheplife-sciences-q-biohuman-health-and-pathology",
        "theses" ;
    dcat:landingPage <https://theses.hal.science/tel-00648421> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00648421v2/resource/7cb1c69c-dcf5-4795-9e68-ede501966c21> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-30T12:40:41.968162"^^xsd:dateTime ;
    dct:modified "2026-05-30T12:40:41.871922"^^xsd:dateTime ;
    dct:title "Innate Immune Response of plasmacytoid dendritic cells during retroviral stimulation (HTLV-1, HIV-1)" ;
    dcat:accessURL <https://theses.hal.science/tel-00648421> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .

<https://theses.hal.science/tel-00648421> a foaf:Document .