@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00069699v2> a dcat:Dataset ;
    dct:description """
              Huntington's disease (HD) is caused by a polyglutamine expansion in the huntingtin protein.<br />This mutation confers new properties on this protein, including the ability to form<br />aggregates and to produce a selective degeneration of striatal neurons, despite a ubiquitous<br />expression of mutated huntingtin. The aim of this work was to explore the role of dopamine<br />in this striatal vulnerability. We first set up an experimental model, using transient<br />transfection in primary cultures of striatal neurons. We showed in that model an activation<br />of the pro-apoptotic JNK/cJun pathway by mutated huntingtin (Garcia, Charvin and Caboche,<br />2004). In a second step, we combined treatments with low doses of dopamine and<br />showed i) a potentiation, via reactive oxygen species (ROS), of JNK/cJun activation induced<br />by mutated huntingtin ; ii) an increase of aggregate formation via D2 receptor<br />stimulation, iii) an amplification of neuronal toxicity via these two combined effects. Thus,<br />our data strongly support that dopamine is involved in striatal neuron vulnerability in HD<br />(Charvin et al., 2005). Then, we have evaluated in vivo, the therapeutic effects of a D2<br />antagonist treatment in a rat model of HD. Rats were infected into the striatum with lentivirus<br />expressing either normal or mutated huntingtin. An early treatment with haloperidol<br />decanoate showed a protection against both aggregate formation and striatal dysfunction<br />(Charvin et al., soumis). Our results highlight a key role of dopamine in striatal neurons<br />vulnerability in HD, and offer new therapeutic strategies for the treatment of HD.
            """ ;
    dct:identifier "tel-00069699" ;
    dct:issued "2026-05-09T19:19:19.840556"^^xsd:dateTime ;
    dct:language "fr" ;
    dct:modified "2026-05-09T19:19:19.840562"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Dopamine and striatal neurodegeneration in Huntington's disease : towards the identification<br />of new therapeutic targets." ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00069699v2/resource/d86671a0-e7b2-4702-a250-71004c682212> ;
    dcat:keyword "2004",
        "2005-05122005",
        "2005-nous-avons-ensuite-evalue-in-vivo-leffet-therapeutique-dun-traitement-precoce-avec-un-antag",
        "biologie-cellulaire",
        "charvin-and-caboche",
        "cjun-n-terminal-kinase",
        "dont-celle-de-sagreger-et-de-produire-une-neurodegenerescence",
        "est-specifique-du-striatum-lobjectif-de-ce-travail-consistait-a-explorer-le-role-de-la-dopamine-da",
        "fiche-de-thesebr-resume",
        "ii-augmente-la-formation-dagregats-via-lactivation-des-recepteurs-d2",
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        "infoeu-reposemanticsdoctoralthesis",
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        "nous-avons-etudie-linfluence-de-la-dopamine-dans-ce-modele-neuronal-nous-avons-alors-montre-que-la",
        "nous-avons-montre-que-lhaloperidol-decanoate-retarde-la-formation-des-agregats-et-protegent-les-neu",
        "pharmacologie",
        "publicationsbr-br-auteur--charvin-delphinebr-dopamine-et-degenerescence-des-neurones-stria",
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        "sdvneulife-sciences-q-bioneurons-and-cognition-q-bionc",
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        "these-nbr-br-formation-doctorale--neurosciencesbr-br-resume-br-br-la-maladie-de",
        "theses" ;
    dcat:landingPage <https://theses.hal.science/tel-00069699> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00069699v2/resource/d86671a0-e7b2-4702-a250-71004c682212> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-09T19:19:19.856466"^^xsd:dateTime ;
    dct:modified "2026-05-09T19:19:19.815949"^^xsd:dateTime ;
    dct:title "Dopamine and striatal neurodegeneration in Huntington's disease : towards the identification<br />of new therapeutic targets." ;
    dcat:accessURL <https://theses.hal.science/tel-00069699> .

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