Influence of promoter polymorphism of HIV-1 subtypes on the dynamic of viral replication in vivo
type: Dataset
description: Viral promoters modulate transcription and hence viral replication. The HIV-1 promoter is polymorph in its transcription factors binding sites. The impact of this polymorphism on viral replication in vivo has never been addressed. On the background of a SIVmac239 genome, we have engineered three chimeras bearing the minimal promoters of HIV-1 clade B, C and E. By co-infection of four rhesus macaques, a discrepancy between the genotypes of rPBMCs-associated chimeras and of virions in the serum has been highlighted. A shift in viral genotype profiles was observed between the acute and the asymptomatic phase. These results show that subtype-specific HIV-1 promoter polymorphism is a major determinant influencing viral replication and dissemination. Notably, primary infection viremia is mainly due to HIV-1 replication in the gut.
issued: 2026-05-29T00:33:55.127511
language: fr
modified: 2026-05-29T00:33:55.127516
contact point: Organization
  fn: CCSD
keyword: hiv-1
keyword: il-7
keyword: infoeu-reposemanticsdoctoralthesis
keyword: ltr
keyword: macaque-rhesus
keyword: primary-infection
keyword: primo-infection
keyword: rhesus-macaque
keyword: sdvbbmbclife-sciences-q-biobiochemistry-molecular-biologybiochemistry-q-biobm
keyword: sous-type
keyword: subtype
keyword: theses
keyword: vih-1
landing page: https://theses.hal.science/tel-00010008

Influence of promoter polymorphism of HIV-1 subtypes on the dynamic of viral replication in vivo
type: Distribution
format: HTML
issued: 2026-05-29T00:33:55.182492
modified: 2026-05-29T00:33:55.094086
access URL: https://theses.hal.science/tel-00010008

test_moissonnage_selune
type: Agent