@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00010008v2> a dcat:Dataset ;
    dct:description """
              Viral promoters modulate transcription and hence viral replication. The HIV-1 promoter is polymorph in its transcription factors binding sites. The impact of this polymorphism on viral replication in vivo has never been addressed. On the background of a SIVmac239 genome, we have engineered three chimeras bearing the minimal promoters of HIV-1 clade B, C and E. By co-infection of four rhesus macaques, a discrepancy between the genotypes of rPBMCs-associated chimeras and of virions in the serum has been highlighted. A shift in viral genotype profiles was observed between the acute and the asymptomatic phase. These results show that subtype-specific HIV-1 promoter polymorphism is a major determinant influencing viral replication and dissemination. Notably, primary infection viremia is mainly due to HIV-1 replication in the gut.
            """ ;
    dct:identifier "tel-00010008" ;
    dct:issued "2026-05-29T00:33:55.127511"^^xsd:dateTime ;
    dct:language "fr" ;
    dct:modified "2026-05-29T00:33:55.127516"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Influence of promoter polymorphism of HIV-1 subtypes on the dynamic of viral replication in vivo" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00010008v2/resource/dd887302-aec1-4a22-b303-e0ca138c3254> ;
    dcat:keyword "hiv-1",
        "il-7",
        "infoeu-reposemanticsdoctoralthesis",
        "ltr",
        "macaque-rhesus",
        "primary-infection",
        "primo-infection",
        "rhesus-macaque",
        "sdvbbmbclife-sciences-q-biobiochemistry-molecular-biologybiochemistry-q-biobm",
        "sous-type",
        "subtype",
        "theses",
        "vih-1" ;
    dcat:landingPage <https://theses.hal.science/tel-00010008> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00010008v2/resource/dd887302-aec1-4a22-b303-e0ca138c3254> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-29T00:33:55.182492"^^xsd:dateTime ;
    dct:modified "2026-05-29T00:33:55.094086"^^xsd:dateTime ;
    dct:title "Influence of promoter polymorphism of HIV-1 subtypes on the dynamic of viral replication in vivo" ;
    dcat:accessURL <https://theses.hal.science/tel-00010008> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .

<https://theses.hal.science/tel-00010008> a foaf:Document .